There are 4 ways to get from Tupelo to Greenville by car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Golden Triangle Regional Airport, fly
best- Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
- Fly from Golden Triangle Regional Airport (GTR) to Greenville–Spartanburg International Airport (GSP)plane GTR - GSP
4h 50m$126–541Drive 418.8 mi
cheapest- Drive from Tupelo to Greenvillecar 418.8 mi
7h 8m$77–111Bus
- Take the bus from Tupelo to Atlanta Bus Stationbus Greyhound US0610
- Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus Charlotte
11h$114–266Fly from Tupelo Regional Airport
- Fly from Tupelo Regional Airport (TUP) to Greenville–Spartanburg International Airport (GSP)plane TUP - GSP
3h 56m$135–552
Golden Triangle Regional Airport (GTR) to Greenville–Spartanburg International Airport (GSP) flights
Questions & Answers
The cheapest way to get from Tupelo to Greenville is to drive which costs $75 - $110 and takes 7h 8m.
The fastest way to get from Tupelo to Greenville is to fly which takes 3h 56m and costs $130 - $550.
No, there is no direct bus from Tupelo to Greenville. However, there are services departing from Tupelo and arriving at Taqueria Guadalajara - Greenville via Atlanta. The journey, including transfers, takes approximately 11h.
The distance between Tupelo and Greenville is 454 miles. The road distance is 421.2 miles.
The best way to get from Tupelo to Greenville without a car is to bus which takes 11h and costs $110 - $270.
It takes approximately 4h 50m to get from Tupelo to Greenville, including transfers.
Tupelo to Greenville bus services, operated by Greyhound USA, depart from Tupelo station.
The best way to get from Tupelo to Greenville is to bus which takes 11h and costs $110 - $270. Alternatively, you can fly, which costs $130 - $550 and takes 3h 56m.
Tupelo to Greenville bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Greenville is 1h ahead of Tupelo. It is currently 1:47 PM in Tupelo and 2:47 PM in Greenville.
What companies run services between Tupelo, MS, USA and Greenville, SC, USA?
You can take a vehicle from Tupelo to Greenville via Tupelo, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 11h. Alternatively, Corporate Flight Management Inc, Southwest Airlines, and two other airlines fly from Tupelo Regional Airport (TUP) to Greenville–Spartanburg International Airport (GSP) twice daily.
- Website
- delta.com
Flights from Golden Triangle Regional Airport to Greenville–Spartanburg International Airport via Atlanta
- Ave. Duration
- 3h 31m
- When
- Every day
- Estimated price
- $80–480
Flights from Tupelo Regional Airport to Greenville–Spartanburg International Airport via Nashville, Atlanta
- Ave. Duration
- 6h 50m
- When
- Every day
- Estimated price
- $95–550
- Website
- southwest.com
Flights from Tupelo Regional Airport to Greenville–Spartanburg International Airport via Nashville
- Ave. Duration
- 4h 57m
- When
- Every day
- Estimated price
- $85–490
- Website
- aa.com
Flights from Golden Triangle Regional Airport to Greenville–Spartanburg International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 32m
- When
- Every day
- Estimated price
- $170–800
Flights from Tupelo Regional Airport to Greenville–Spartanburg International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 18m
- When
- Sunday
- Estimated price
- $170–800
Flights from Tupelo Regional Airport to Greenville–Spartanburg International Airport via Nashville, Charlotte
- Ave. Duration
- 6h 30m
- When
- Sunday
- Estimated price
- $95–550
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Tupelo to Atlanta Bus Station
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $40–80
- Website
- https://www.greyhound.com/
- Phone
- +1 888 358 6762
- [email protected]
- Website
- tornadobus.com
Bus from Atlanta to Taqueria Guadalajara - Greenville
- Ave. Duration
- 3h 22m
- Frequency
- Once daily
- Estimated price
- $45–150
- Schedules at
- tornadobus.com
- Adults 11-59
- $45–150
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More Questions & Answers
Yes, the driving distance between Tupelo to Greenville is 421 miles. It takes approximately 7h 8m to drive from Tupelo to Greenville.
Book your Tupelo to Greenville bus tickets online with Omio.
There are 273+ hotels available in Greenville.