Rome2Rio

How to get fromTupelo to Indianaby bus, plane, train, bus (Greyhound, Flixbus, Amtrak), car, bus (Greyhound, Flixbus), or bus (Greyhound)

Find Transport to Indiana

See all options

There are 8 ways to get from Tupelo to Indiana by bus, plane, train, bus (Greyhound, Flixbus, Amtrak), car, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly to Chicago O'Hare International Airport, train

    best
    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Chicago O'Hare International Airport (ORD)plane plane MEM - ORD
    3. Take the train from Van Buren St. to Gary Metro Centertrain train
    7h 58m
    $92–395

  2. Drive  464.4 mi

    cheapest
    1. Drive from Tupelo to Indianapoliscar car 464.4 mi
    9h 33m
    $85–123

  3. Bus

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus
    13h 39m
    $101–149

  4. Bus, fly to Chicago Midway International Airport, train

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Chicago Midway International Airport (MDW)plane plane MEM - MDW
    3. Take the train from Museum Campus/11th St. to Gary Metro Centertrain train
    7h 31m
    $107–485

  5. Bus, fly to Nashville

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Nashville (BNA)plane plane MEM - BNA
    3. Take the bus from Nashville Bus Station to Evansville Bus Stationbus bus
    9h 32m
    $532–782

  6. Bus via St. Louis

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    13h 54m
    $101–174

  7. Bus via Indianapolis

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Indianapolisbus bus
    14h 39m
    $101–169

  8. Bus #2

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus Greyhound US0610
    2. Take the bus from Tornado Bus Co - West Memphis to Indianapolisbus bus Memphis
    14h 47m
    $159–197

Memphis (MEM) to Chicago O'Hare International Airport (ORD) flights

Calendar103Weekly Planes
Duration3h 16mAverage Duration
Ticket$56Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Tupelo to Indiana.ExpandLaunch map view
  • Distance: 644.7 mi
  • Duration: 7h 58m

What companies run services between Tupelo, MS, USA and Indiana, USA?

You can take a vehicle from Tupelo to Indianapolis Union Station via Tupelo, Memphis Bus Station, and Nashville Bus Station in around 13h 39m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There