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How to get fromTupelo to Indianapolisby car, plane, bus (Greyhound, Flixbus, Amtrak), bus, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 7 ways to get from Tupelo to Indianapolis by car, plane, bus (Greyhound, Flixbus, Amtrak), bus, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Indianapolis (IND)plane plane GTR - IND
    6h 26m
    $113–618

  2. Drive  464.4 mi

    cheapest
    1. Drive from Tupelo to Indianapoliscar car 464.4 mi
    9h 33m
    $85–123

  3. Bus

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus
    13h 39m
    $101–149

  4. Bus to Memphis, fly

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Indianapolis (IND)plane plane MEM - IND
    8h 20m
    $129–642

  5. Bus via St. Louis

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    13h 54m
    $101–174

  6. Bus #2

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Champaign Intermodal Trans Ctrbus bus
    3. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    14h 24m
    $114–179

  7. Bus #3

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus Greyhound US0610
    2. Take the bus from Tornado Bus Co - West Memphis to Indianapolisbus bus Memphis
    14h 47m
    $159–197

Golden Triangle Regional Airport (GTR) to Indianapolis (IND) flights

Calendar21Weekly Planes
Duration5h 35mAverage Duration
Ticket$101Cheapest Price
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Comparing Your Travel Options

Map of how to get from Tupelo to Indianapolis.ExpandLaunch map view
  • Distance: 527.7 mi
  • Duration: 6h 26m

What companies run services between Tupelo, MS, USA and Indianapolis, IN, USA?

You can take a vehicle from Tupelo to Indianapolis Union Station via Tupelo, Memphis Bus Station, and Nashville Bus Station in around 13h 39m.

Airlines
Bus operators

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