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How to get fromTupelo to Knoxvilleby car, plane, bus, or shuttle

Find Transport to Knoxville

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There are 5 ways to get from Tupelo to Knoxville by car, plane, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS)plane plane GTR - TYS
    4h 45m
    $176–786

  2. Drive  347.1 mi

    cheapest
    1. Drive from Tupelo to Knoxvillecar car 347.1 mi
    6h 23m
    $64–92

  3. Bus, shuttle, drive

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    20h 24m
    $338–410

  4. Bus to Memphis, fly

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Mcghee Tyson Airport (TYS)plane plane MEM - TYS
    5h 30m
    $212–960

  5. Bus, shuttle, drive via Atlanta

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Downtown to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    20h 33m
    $341–408

Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS) flights

Calendar20Weekly Planes
Duration4h 40mAverage Duration
Ticket$115Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Tupelo to Knoxville.ExpandLaunch map view
  • Distance: 382.5 mi
  • Duration: 4h 45m

What companies run services between Tupelo, MS, USA and Knoxville, TN, USA?

There is no direct connection from Tupelo to Knoxville. However, you can drive to Golden Triangle Regional Airport (GTR) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a vehicle from Tupelo to Knoxville via Tupelo, Atlanta Bus Station, Charlotte, Boone, Boone, Black Bear Resort, and Hot Springs in around 20h 24m.

Airlines
Bus operators

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