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How to get fromTupelo to Knoxvilleby car, plane, bus, or shuttle

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There are 6 ways to get from Tupelo to Knoxville by car, plane, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly to Mcghee Tyson Airport

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS)plane plane GTR - TYS
    4h 56m
    $161–686

  2. Drive 347.1 mi

    cheapest
    1. Drive from Tupelo to Knoxvillecar car 347.1 mi
    6h 24m
    $64–92

  3. Bus, shuttle, drive

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    19h 34m
    $446–566

  4. Fly Tupelo Regional Airport to Nashville, drive

    1. Fly from Tupelo Regional Airport (TUP) to Nashville (BNA)plane plane TUP - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 2m
    $100–237

  5. Bus to Memphis, fly to Mcghee Tyson Airport

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Mcghee Tyson Airport (TYS)plane plane MEM - TYS
    5h 30m
    $203–870

  6. Fly Tupelo Regional Airport to Mcghee Tyson Airport

    1. Fly from Tupelo Regional Airport (TUP) to Mcghee Tyson Airport (TYS)plane plane TUP - TYS
    3h 35m
    $180–737

Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS) flights

Calendar17Weekly Planes
Duration4h 16mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Tupelo to Knoxville.ExpandLaunch map view
  • Distance: 382.5 mi
  • Duration: 4h 56m

What companies run services between Tupelo, MS, USA and Knoxville, TN, USA?

Corporate Flight Management Inc, Southwest Airlines, and two other airlines fly from Tupelo Regional Airport (TUP) to Mcghee Tyson Airport (TYS) twice daily.

Airlines
Bus operators

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