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How to get fromTupelo to Knoxvilleby car, plane, bus, or shuttle

Find Transport to Knoxville

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There are 7 ways to get from Tupelo to Knoxville by car, plane, bus, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly to Mcghee Tyson Airport

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS)plane plane GTR - TYS
    4h 46m
    $186–886

  2. Drive  347.1 mi

    cheapest
    1. Drive from Tupelo to Knoxvillecar car 347.1 mi
    6h 23m
    $64–92

  3. Bus, shuttle, drive via Atlanta

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Downtown to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    20h 33m
    $346–408

  4. Fly Tupelo Regional Airport to Nashville, drive

    1. Fly from Tupelo Regional Airport (TUP) to Nashville (BNA)plane plane TUP - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 2m
    $100–237

  5. Bus to Memphis, fly to Mcghee Tyson Airport

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Mcghee Tyson Airport (TYS)plane plane MEM - TYS
    5h 33m
    $223–1,011

  6. Fly Tupelo Regional Airport to Mcghee Tyson Airport

    1. Fly from Tupelo Regional Airport (TUP) to Mcghee Tyson Airport (TYS)plane plane TUP - TYS
    3h 25m
    $210–937

  7. Bus, shuttle, drive

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    20h 34m
    $343–415

Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS) flights

Calendar12Weekly Planes
Duration4h 29mAverage Duration
Ticket$122Cheapest Price
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Comparing Your Travel Options

Map of how to get from Tupelo to Knoxville.ExpandLaunch map view
  • Distance: 382.5 mi
  • Duration: 4h 46m

What companies run services between Tupelo, MS, USA and Knoxville, TN, USA?

Corporate Flight Management Inc, Southwest Airlines, and two other airlines fly from Tupelo Regional Airport (TUP) to Mcghee Tyson Airport (TYS) 3 times a day.

Airlines
Bus operators

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