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How to get fromTupelo to Lexingtonby bus, car, or plane

Find Transport to Lexington

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There are 5 ways to get from Tupelo to Lexington by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive via Nashville

    best
    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    14h 33m
    $95–163

  2. Drive to Golden Triangle Regional Airport, fly

    cheapest
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Blue Grass Airport (LEX)plane plane GTR - LEX
    9h 10m
    $73–388

  3. Drive  412.1 mi

    1. Drive from Tupelo to Lexingtoncar car 412.1 mi
    8h
    $76–109

  4. Bus, drive

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    15h 26m
    $140–186

  5. Bus to Memphis, fly

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Blue Grass Airport (LEX)plane plane MEM - LEX
    9h 59m
    $109–512

Golden Triangle Regional Airport (GTR) to Blue Grass Airport (LEX) flights

Calendar20Weekly Planes
Duration5h 59mAverage Duration
Ticket$63Cheapest Price
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Comparing Your Travel Options

Map of how to get from Tupelo to Lexington.ExpandLaunch map view
  • Distance: 578.2 mi
  • Duration: 14h 33m

What companies run services between Tupelo, MS, USA and Lexington, KY, USA?

There is no direct connection from Tupelo to Lexington. However, you can take the taxi to Tupelo, take the bus to Memphis Bus Station, take the bus to Nashville Bus Station, take the bus to Louisville Bus Station, walk to Chestnut @ 13th, take the line 21 bus to Chestnut @ 8th, walk to S 5th @ W Jefferson, take the line 31 bus to Middletown Station @ Target, then drive to Lexington. Alternatively, you can drive from Tupelo to Lexington in around 8h.

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