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How to get fromTupelo to Louisvilleby car, plane, bus (Greyhound, Flixbus, Amtrak), bus, or bus (Greyhound)

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There are 7 ways to get from Tupelo to Louisville by car, plane, bus (Greyhound, Flixbus, Amtrak), bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly to Louisville International Airport

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Louisville International Airport (SDF)plane plane GTR - SDF
    5h 52m
    $122–668

  2. Drive  370.6 mi

    cheapest
    1. Drive from Tupelo to Louisvillecar car 370.6 mi
    7h 18m
    $64–92

  3. Bus via Nashville

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    11h 24m
    $89–151

  4. Fly Tupelo Regional Airport to Nashville, bus

    1. Fly from Tupelo Regional Airport (TUP) to Nashville (BNA)plane plane TUP - BNA
    2. Take the bus from Nashville to Louisville, KYbus bus
    6h 32m
    $102–219

  5. Fly Tupelo Regional Airport to Louisville International Airport

    1. Fly from Tupelo Regional Airport (TUP) to Louisville International Airport (SDF)plane plane TUP - SDF
    4h 25m
    $246–770

  6. Bus to Memphis, fly to Louisville International Airport

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Louisville International Airport (SDF)plane plane MEM - SDF
    8h 10m
    $141–795

  7. Bus

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus Greyhound US0610
    2. Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus bus Memphis
    12h 18m
    $131–170

Golden Triangle Regional Airport (GTR) to Louisville International Airport (SDF) flights

Calendar20Weekly Planes
Duration5hAverage Duration
Ticket$111Cheapest Price
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Comparing Your Travel Options

Map of how to get from Tupelo to Louisville.ExpandLaunch map view
  • Distance: 431.9 mi
  • Duration: 5h 52m

What companies run services between Tupelo, MS, USA and Louisville, KY, USA?

You can take a vehicle from Tupelo to Louisville, KY via Tupelo, Memphis Bus Station, and Nashville in around 11h 24m. Alternatively, Corporate Flight Management Inc, Southwest Airlines, and American Airlines fly from Tupelo Regional Airport (TUP) to Louisville International Airport (SDF) twice daily.

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Bus operators

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