Rome2Rio

How to get fromTupelo to Louisvilleby car, plane, bus (Greyhound, Flixbus, Amtrak), bus, or bus (Greyhound)

Find Transport to Louisville

See all options

There are 7 ways to get from Tupelo to Louisville by car, plane, bus (Greyhound, Flixbus, Amtrak), bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly to Louisville International Airport

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Louisville International Airport (SDF)plane plane GTR - SDF
    6h 8m
    $122–669

  2. Drive  370.6 mi

    cheapest
    1. Drive from Tupelo to Louisvillecar car 370.6 mi
    7h 18m
    $68–98

  3. Bus via Nashville

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    11h 24m
    $87–144

  4. Fly Tupelo Regional Airport to Nashville, bus

    1. Fly from Tupelo Regional Airport (TUP) to Nashville (BNA)plane plane TUP - BNA
    2. Take the bus from Nashville to Louisville, KYbus bus
    6h 32m
    $102–239

  5. Fly Tupelo Regional Airport to Louisville International Airport

    1. Fly from Tupelo Regional Airport (TUP) to Louisville International Airport (SDF)plane plane TUP - SDF
    4h 35m
    $136–720

  6. Bus to Memphis, fly to Louisville International Airport

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Louisville International Airport (SDF)plane plane MEM - SDF
    8h 20m
    $129–743

  7. Bus

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus Greyhound US0610
    2. Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus bus Memphis
    12h 18m
    $129–168

Golden Triangle Regional Airport (GTR) to Louisville International Airport (SDF) flights

Calendar21Weekly Planes
Duration5h 22mAverage Duration
Ticket$110Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Tupelo to Louisville.ExpandLaunch map view
  • Distance: 431.9 mi
  • Duration: 6h 8m

What companies run services between Tupelo, MS, USA and Louisville, KY, USA?

You can take a vehicle from Tupelo to Louisville, KY via Tupelo, Memphis Bus Station, and Nashville in around 11h 24m. Alternatively, Corporate Flight Management Inc, Southwest Airlines, and two other airlines fly from Tupelo Regional Airport (TUP) to Louisville International Airport (SDF) twice daily.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There