There are 7 ways to get from Tupelo to Louisville by car, plane, bus (Greyhound, Flixbus, Amtrak), bus, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Golden Triangle Regional Airport, fly to Louisville International Airport
best- Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
- Fly from Golden Triangle Regional Airport (GTR) to Louisville International Airport (SDF)plane GTR - SDF
6h 1m$112–669Drive 370.4 mi
cheapest- Drive from Tupelo to Louisvillecar 370.4 mi
7h 18m$68–98Bus via Nashville
- Take the bus from Tupelo to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Nashville Bus Stationbus
- Take the bus from Nashville Bus Station to Louisville Bus Stationbus
10h 54m$82–139Fly Tupelo Regional Airport to Nashville, bus
- Fly from Tupelo Regional Airport (TUP) to Nashville (BNA)plane TUP - BNA
- Take the bus from Nashville Bus Station to Louisville Bus Stationbus
6h 2m$98–234Bus to Memphis, fly to Louisville International Airport
- Take the bus from Tupelo to Memphis Bus Stationbus
- Fly from Memphis (MEM) to Louisville International Airport (SDF)plane MEM - SDF
8h 3m$128–743Fly Tupelo Regional Airport to Louisville International Airport
- Fly from Tupelo Regional Airport (TUP) to Louisville International Airport (SDF)plane TUP - SDF
4h 30m$206–820Bus
- Take the bus from Tupelo to Memphis Bus Stationbus Greyhound US0610
- Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus Memphis
12h 21m$128–168
Golden Triangle Regional Airport (GTR) to Louisville International Airport (SDF) flights
Questions & Answers
The cheapest way to get from Tupelo to Louisville is to drive which costs $65 - $100 and takes 7h 18m.
The fastest way to get from Tupelo to Louisville is to fly which takes 4h 30m and costs $200 - $850.
No, there is no direct bus from Tupelo to Louisville station. However, there are services departing from Tupelo and arriving at Louisville Bus Station via Memphis Bus Station and Nashville Bus Station. The journey, including transfers, takes approximately 10h 54m.
The distance between Tupelo and Louisville is 434 miles. The road distance is 372.6 miles.
The best way to get from Tupelo to Louisville without a car is to bus via Nashville which takes 10h 54m and costs $80 - $140.
It takes approximately 6h 1m to get from Tupelo to Louisville, including transfers.
Tupelo to Louisville bus services, operated by Greyhound USA, depart from Tupelo station.
The best way to get from Tupelo to Louisville is to bus via Nashville which takes 10h 54m and costs $80 - $140. Alternatively, you can fly, which costs $200 - $850 and takes 4h 30m.
Tupelo to Louisville bus services, operated by Greyhound USA, arrive at Memphis Bus Station.
Louisville is 1h ahead of Tupelo. It is currently 7:39 PM in Tupelo and 8:39 PM in Louisville.
What companies run services between Tupelo, MS, USA and Louisville, KY, USA?
You can take a vehicle from Tupelo to Louisville Bus Station via Tupelo, Memphis Bus Station, and Nashville Bus Station in around 10h 54m. Alternatively, Corporate Flight Management Inc, Southwest Airlines, and American Airlines fly from Tupelo Regional Airport (TUP) to Louisville International Airport (SDF) once daily.
- Website
- southwest.com
Flights from Memphis to Louisville International Airport via Nashville
- Ave. Duration
- 3h 51m
- When
- Every day
- Estimated price
- $100–700
Flights from Memphis to Louisville International Airport via Chicago Midway
- Ave. Duration
- 4h 2m
- When
- Monday, Thursday, Friday, Tuesday, Wednesday, and Sunday
- Estimated price
- $160–850
Flights from Memphis to Louisville International Airport via Dallas
- Ave. Duration
- 5h
- When
- Tuesday and Wednesday
- Estimated price
- $210–1,100
Flights from Tupelo Regional Airport to Louisville International Airport via Nashville
- Ave. Duration
- 3h 18m
- When
- Saturday, Tuesday, and Wednesday
- Estimated price
- $190–800
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Bus from Memphis Bus Station to Nashville Bus Station
- Ave. Duration
- 3h 50m
- Frequency
- 4 times a day
- Estimated price
- $30–55
- Website
- Greyhound
Bus from Nashville Bus Station to Louisville Bus Station
- Ave. Duration
- 3h 10m
- Frequency
- Every 4 hours
- Estimated price
- $27–45
- Website
- Greyhound
Bus from Nashville Bus Station to Louisville Bus Station
- Ave. Duration
- 3h 10m
- Frequency
- Every 4 hours
- Estimated price
- $27–45
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
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More Questions & Answers
Yes, the driving distance between Tupelo to Louisville is 373 miles. It takes approximately 7h 18m to drive from Tupelo to Louisville.
Book your Tupelo to Louisville bus tickets online with Omio.
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