There are 6 ways to get from Tupelo to Sedalia by bus, train, car, plane, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from Tupelo to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to St Louis Bus Stationbus
- Take the train from St. Louis to Sedalia Amtrak Stationtrain
12h 41m$174–281Drive 470.1 mi
cheapest- Drive from Tupelo to Sedaliacar 470.1 mi
9h 7m$86–124Fly to Columbia Regional Airport, drive
- Fly from Tupelo Regional Airport (TUP) to Columbia Regional Airport (COU)plane TUP - COU
- Drive from Columbia Regional Airport (COU) to Sedaliacar
7h 55m$114–479Bus
- Take the bus from Tupelo to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to La Montebus
14h 47m$154–236Fly to Lambert–St. Louis International Airport, train
- Fly from Tupelo Regional Airport (TUP) to Lambert–St. Louis International Airport (STL)plane TUP - STL
- Take the train from St. Louis to Sedalia Amtrak Stationtrain
10h 23m$193–650Fly to Kansas City, train
- Fly from Tupelo Regional Airport (TUP) to Kansas City (MCI)plane TUP - MCI
- Take the train from Kansas City to Sedalia Amtrak Stationtrain
9h 29m$165–697
Tupelo Regional Airport (TUP) to Columbia Regional Airport (COU) flights
Comparing Your Travel Options
The cheapest way to get from Tupelo to Sedalia is to drive which costs $85 - $130 and takes 9h 7m.
The fastest way to get from Tupelo to Sedalia is to fly and drive which takes 7h 55m and costs $110 - $480.
No, there is no direct bus from Tupelo to Sedalia. However, there are services departing from Tupelo and arriving at La Monte via Memphis Bus Station and St Louis Bus Station. The journey, including transfers, takes approximately 14h 47m.
The distance between Tupelo and Sedalia is 584 miles. The road distance is 472.8 miles.
The best way to get from Tupelo to Sedalia without a car is to bus and train which takes 12h 41m and costs $170 - $290.
It takes approximately 12h 41m to get from Tupelo to Sedalia, including transfers.
Tupelo to Sedalia bus services, operated by Greyhound USA, depart from Tupelo station.
Tupelo to Sedalia bus services, operated by Greyhound USA, arrive at Memphis Bus Station.
Yes, the driving distance between Tupelo to Sedalia is 473 miles. It takes approximately 9h 7m to drive from Tupelo to Sedalia.
Book your Tupelo to Sedalia bus tickets online with Omio.
What companies run services between Tupelo, MS, USA and Sedalia, MO, USA?
You can take a vehicle from Tupelo to Sedalia via Tupelo, Memphis Bus Station, St Louis Bus Station, and La Monte in around 14h 47m.
- Website
- aa.com
Flights from Tupelo Regional Airport to Columbia Regional Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 2m
- When
- Monday, Wednesday, Thursday, and Sunday
- Estimated price
- $90–450
Flights from Tupelo Regional Airport to Columbia Regional Airport via Nashville, Charlotte
- Ave. Duration
- 8h 19m
- When
- Saturday
- Estimated price
- $100–490
Flights from Tupelo Regional Airport to Columbia Regional Airport via Nashville, Chicago O'Hare
- Ave. Duration
- 9h 52m
- When
- Monday, Friday, and Saturday
- Estimated price
- $85–440
Flights from Tupelo Regional Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 2m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $120–650
Flights from Tupelo Regional Airport to Kansas City via Dallas/Ft.Worth
- Ave. Duration
- 4h 59m
- When
- Sunday, Tuesday, and Saturday
- Estimated price
- $370–1,400
- Website
- southwest.com
Flights from Tupelo Regional Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 5h 50m
- When
- Tuesday, Wednesday, and Sunday
- Estimated price
- $75–470
Flights from Tupelo Regional Airport to Lambert–St. Louis International Airport via Nashville, Chicago Midway
- Ave. Duration
- 7h 55m
- When
- Monday, Thursday, and Friday
- Estimated price
- $100–600
Flights from Tupelo Regional Airport to Lambert–St. Louis International Airport via Nashville, Kansas City
- Ave. Duration
- 9h 20m
- When
- Tuesday and Wednesday
- Estimated price
- $110–600
Flights from Tupelo Regional Airport to Kansas City via Nashville
- Ave. Duration
- 4h 52m
- When
- Sunday, Monday, Thursday, and Friday
- Estimated price
- $100–600
Flights from Tupelo Regional Airport to Kansas City via Nashville, Indianapolis
- Ave. Duration
- 6h 20m
- When
- Tuesday and Wednesday
- Estimated price
- $120–700
Flights from Tupelo Regional Airport to Kansas City via Nashville, Lambert–St. Louis International Airport
- Ave. Duration
- 7h 50m
- When
- Monday, Thursday, and Friday
- Estimated price
- $110–600
- Website
- united.com
Flights from Tupelo Regional Airport to Columbia Regional Airport via Nashville, Chicago O'Hare
- Ave. Duration
- 7h 38m
- When
- Sunday
- Estimated price
- $85–440
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from St. Louis to Sedalia Amtrak Station
- Ave. Duration
- 3h 32m
- Frequency
- Twice daily
- Estimated price
- $100–160
- Website
- Amtrak
Train from St. Louis to Sedalia Amtrak Station
- Ave. Duration
- 3h 32m
- Frequency
- Twice daily
- Estimated price
- $100–160
- Website
- Amtrak
Train from Kansas City to Sedalia Amtrak Station
- Ave. Duration
- 1h 47m
- Frequency
- Twice daily
- Estimated price
- $50–80
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Estimated price
- $50–80
- Website
- Greyhound
Bus from Tupelo to Memphis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Twice daily
- Estimated price
- $18–27
- Website
- Greyhound
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 15m
- Frequency
- Once daily
- Estimated price
- $50–80
- Website
- Greyhound
Bus from St Louis Bus Station to La Monte
- Ave. Duration
- 5h 25m
- Frequency
- Once daily
- Estimated price
- $40–65
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- 5 times a week
- Estimated price
- $45–70
- Schedules at
- Flixbus USA
Bus from Memphis Bus Station to St Louis Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- 5 times a week
- Estimated price
- $45–70
- Schedules at
- Flixbus USA
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Booking & Getting There
There are 19+ hotels available in Sedalia.







