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How to get fromTupelo to Sioux Fallsby car, plane, bus (Greyhound), bus, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Tupelo to Sioux Falls by car, plane, bus (Greyhound), bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Sioux Falls (FSD)plane plane GTR - FSD
    8h 4m
    $123–508

  2. Fly from Tupelo Regional Airport

    cheapest
    1. Fly from Tupelo Regional Airport (TUP) to Sioux Falls (FSD)plane plane TUP - FSD
    8h 10m
    $117–479

  3. Bus

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Kansas Citybus bus
    3. Take the bus from Kansas City to Des Moinesbus bus
    4. Take the bus from Des Moines to Omaha, NEbus bus
    5. Take the bus from Omaha to Sioux Fallsbus bus
    26h 27m
    $260–401

  4. Drive 905.5 mi

    1. Drive from Tupelo to Sioux Fallscar car 905.5 mi
    15h 42m
    $166–239

  5. Drive to Huntsville International Airport-Carl T Jones Field, fly

    1. Drive from Tupelo to Huntsville International Airport-Carl T Jones Field (HSV)car car
    2. Fly from Huntsville International Airport-Carl T Jones Field (HSV) to Sioux Falls (FSD)plane plane HSV - FSD
    9h 3m
    $135–585

  6. Bus to Memphis, fly

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Sioux Falls (FSD)plane plane MEM - FSD
    9h 35m
    $140–647

  7. Bus via St. Louis

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    4. Take the bus from Des Moines to Omaha, NEbus bus
    5. Take the bus from Omaha to Sioux Fallsbus bus
    26h 52m
    $210–386

Golden Triangle Regional Airport (GTR) to Sioux Falls (FSD) flights

Calendar28Weekly Planes
Duration8h 25mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Tupelo to Sioux Falls.ExpandLaunch map view
  • Distance: 893.6 mi
  • Duration: 8h 4m

What companies run services between Tupelo, MS, USA and Sioux Falls, SD, USA?

You can take a vehicle from Tupelo to The Bus Stop via Tupelo, Memphis Bus Station, Kansas City, Des Moines, Omaha, Sioux Falls, and Maple/Career NE corner in around 26h 27m. Alternatively, Corporate Flight Management Inc, American Airlines, and Delta fly from Tupelo Regional Airport (TUP) to Sioux Falls (FSD) 4 times a day.

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Bus operators

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