Rome2Rio

How to get fromTupelo to South Carolinaby car, plane, taxi, bus, train, bus (Greyhound, Flixbus), or bus (Greyhound)

Find Transport to South Carolina

See all options

There are 10 ways to get from Tupelo to South Carolina by car, plane, taxi, bus, train, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Northwest Alabama Regional Airport, fly to Charlotte Douglas International Airport, taxi

    best
    1. Drive from Tupelo to Northwest Alabama Regional Airport (MSL)car car
    2. Fly from Northwest Alabama Regional Airport (MSL) to Charlotte Douglas International Airport (CLT)plane plane MSL - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 1m
    $275–822

  2. Fly Tupelo Regional Airport to Charleston International Airport

    cheapest
    1. Fly from Tupelo Regional Airport (TUP) to Charleston International Airport (CHS)plane plane TUP - CHS
    5h 6m
    $92–409

  3. Bus, train

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Savannahbus bus
    3. Take the train from Savannah Station to Charleston Amtrak Stationtrain train
    13h 47m

  4. Drive 562.5 mi

    1. Drive from Tupelo to Charlestoncar car 562.5 mi
    10h 10m
    $103–149

  5. Drive to Birmingham–Shuttlesworth International Airport, fly to Charlotte Douglas International Airport, taxi

    1. Drive from Tupelo to Birmingham-Airport-BHMcar car
    2. Fly from Birmingham–Shuttlesworth International Airport (BHM) to Charlotte Douglas International Airport (CLT)plane plane BHM - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 34m
    $204–785

  6. Drive to Huntsville International Airport-Carl T Jones Field, fly to Charlotte Douglas International Airport, taxi

    1. Drive from Tupelo to Huntsville International Airport-Carl T Jones Field (HSV)car car
    2. Fly from Huntsville International Airport-Carl T Jones Field (HSV) to Charlotte Douglas International Airport (CLT)plane plane HSV - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 42m
    $193–733

  7. Fly Tupelo Regional Airport to Greenville–Spartanburg International Airport

    1. Fly from Tupelo Regional Airport (TUP) to Greenville–Spartanburg International Airport (GSP)plane plane TUP - GSP
    3h 56m
    $135–552

  8. Bus to Memphis, fly to Charlotte Douglas International Airport, taxi

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Charlotte Douglas International Airport (CLT)plane plane MEM - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    6h 26m
    $227–845

  9. Bus via Savannah

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Savannah Bus Stationbus bus
    3. Take the bus from Savannah Bus Station to Charleston Bus Stationbus bus
    15h 44m
    $107–213

  10. Bus

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus Greyhound US0610
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    20h 6m
    $125–243

Northwest Alabama Regional Airport (MSL) to Charlotte Douglas International Airport (CLT) flights

Calendar12Weekly Planes
Duration1h 35mAverage Duration
Ticket$180Cheapest Price
See schedules

Questions & Answers

Map of how to get from Tupelo to South Carolina.ExpandLaunch map view
  • Distance: 490.9 mi
  • Duration: 4h 1m

What companies run services between Tupelo, MS, USA and South Carolina, USA?

Corporate Flight Management Inc, Southwest Airlines, and two other airlines fly from Tupelo Regional Airport (TUP) to Greenville–Spartanburg International Airport (GSP) twice daily. Alternatively, you can take a vehicle from Tupelo to Transit Mall via Tupelo, Atlanta Bus Station, Savannah Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 15h 44m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers