There are 5 ways to get from Tuscany to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Trenitalia)
best- Take the train from Firenze S.M.N. to Roma Terminitrain Fr
- Take the train from Roma Termini to Iserniatrain Re
4h 44m€51–116Bus
cheapest- Take the bus from Florence to Roma, Autostazione Tiburtinabus N520 / ...
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h 35m€22–57Drive 428.2 km
- Drive from Florence to Iserniacar 428.2 km
4h 6m€67–96Fly, train
- Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane FLR - FCO
- Take the train from Roma Termini to Iserniatrain
5h 53m€89–239Train via Firenze Santa Maria Novella
- Take the train from Firenze Santa Maria Novella to Roma Terminitrain 8111 / ...
- Take the train from Roma Termini to Iserniatrain Re
5h 15m€57–105
Tuscany to Isernia by train (Trenitalia)
Questions & Answers
The cheapest way to get from Tuscany to Isernia is to bus which costs €22 - €60 and takes 6h 35m.
The fastest way to get from Tuscany to Isernia is to drive which takes 4h 6m and costs €65 - €100.
No, there is no direct bus from Tuscany to Isernia. However, there are services departing from Florence and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 35m.
No, there is no direct train from Tuscany to Isernia. However, there are services departing from Firenze S.M.N. and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 4h 44m.
The distance between Tuscany and Isernia is 447 km. The road distance is 428.2 km.
The best way to get from Tuscany to Isernia without a car is to train which takes 4h 44m and costs €50 - €120.
It takes approximately 4h 44m to get from Tuscany to Isernia, including transfers.
Tuscany to Isernia bus services, operated by FlixBus, depart from Florence station.
Tuscany to Isernia train services, operated by Trenitalia Frecce, depart from Firenze S.M.N. station.
The best way to get from Tuscany to Isernia is to train which takes 4h 44m and costs €50 - €120. Alternatively, you can bus, which costs €22 - €60 and takes 6h 35m.
What companies run services between Tuscany, Italy and Isernia, Italy?
You can take a train from Firenze S.M.N. to Isernia via Roma Termini in around 4h 44m. Alternatively, you can take a bus from Florence to Isernia via Roma, Autostazione Tiburtina in around 6h 35m.
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Fiumicino International Airport
- Ave. Duration
- 53 min
- When
- Every day
- Estimated price
- €60–180
- Phone
- +39 06 68475475
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 36m
- Frequency
- Every 15 minutes
- Estimated price
- €35–80
- Schedules at
- Trenitalia Frecce
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 3h 51m
- Frequency
- Every 4 hours
- Estimated price
- €30–55
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €23–40
- Website
- Trenitalia
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 2h 40m
- Frequency
- Twice daily
- Estimated price
- €27–60
- Website
- Trenitalia Intercity
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Firenze Santa Maria Novella to Roma Termini
- Ave. Duration
- 2h 7m
- Frequency
- Every 30 minutes
- Estimated price
- €30–65
- Website
- Italo Treno
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Florence to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- €21–35
- Website
- Flixbus
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- €13–22
- Website
- Flixbus
- Phone
- +39081/969167
- [email protected]
- Website
- TTI Leonettibus SRL
Bus from Florence to Roma, Autostazione Tiburtina
- Ave. Duration
- 3h
- Frequency
- Once a week
- Estimated price
- €14–20
- Website
- TTI Leonettibus SRL
- Phone
- +39 0874 64744
- [email protected]
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Want to know more about travelling around Italy
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More Questions & Answers
Tuscany to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Tuscany to Isernia train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
Yes, the driving distance between Tuscany to Isernia is 428 km. It takes approximately 4h 6m to drive from Tuscany to Isernia.
Book your Tuscany to Isernia train tickets online with Omio.
Book your Tuscany to Isernia bus tickets online with Omio and FlixBus.
There are 482+ hotels available in Isernia.