There are 4 ways to get from Tustin to Otay Mesa by bus (Flixbus, Greyhound), train, tram, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Santa Ana to San Ysidrobus Lxus 3105 / ...
2h 42m$21–42Drive 103 mi
cheapest- Drive from Tustin to Otay Mesacar 103 mi
1h 50m$19–28Train, tram
- Take the train from Santa Ana to San Diego Old Town Transportation Centertrain Pacific Surfliner
- Take the tram from Old Town Station to Iris Avenue Stationtram Blue
3h 14m$33–76Bus, line 929 bus
- Take the bus from Santa Ana to San Diegobus Los Angeles
- Take the bus from 12th & Imperial Transit Center to Iris Avenue Transit Centerbus 929 / ...
3h 26m$23–38
Tustin to Otay Mesa by bus
Questions & Answers
The cheapest way to get from Tustin to Otay Mesa is to drive which costs $18 - $28 and takes 1h 50m.
The fastest way to get from Tustin to Otay Mesa is to drive which takes 1h 50m and costs $18 - $28.
No, there is no direct bus from Tustin to Otay Mesa. However, there are services departing from Santa Ana and arriving at Otay Mesa Rd & Cactus Rd via San Ysidro Transit Center and Iris Avenue Transit Center. The journey, including transfers, takes approximately 2h 42m.
No, there is no direct train from Tustin to Otay Mesa station. However, there are services departing from Santa Ana and arriving at Iris Avenue Station via Old Town Station. The journey, including transfers, takes approximately 3h 14m.
The distance between Tustin and Otay Mesa is 118 miles. The road distance is 103.6 miles.
The best way to get from Tustin to Otay Mesa without a car is to bus which takes 2h 42m and costs $20 - $45.
It takes approximately 2h 42m to get from Tustin to Otay Mesa, including transfers.
Tustin to Otay Mesa bus services, operated by Limousine Express, depart from Santa Ana station.
Tustin to Otay Mesa train services, operated by Amtrak, depart from Santa Ana station.
Tustin to Otay Mesa bus services, operated by Limousine Express, arrive at San Ysidro station.
What companies run services between Tustin, CA, USA and Otay Mesa, CA, USA?
Limousine Express operates a bus from Santa Ana to San Ysidro 5 times a day, and the journey takes 1h 50m. Four other operators also service this route.
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Santa Ana to San Diego Old Town Transportation Center
- Ave. Duration
- 1h 51m
- Frequency
- Hourly
- Estimated price
- $29–60
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 619-557-4555
- Website
- sdmts.com
Tram from Old Town Station to Iris Avenue Station
- Ave. Duration
- 50 min
- Frequency
- Every 20 minutes
- Estimated price
- $2–12
- Website
- https://www.sdmts.com
- Schedules at
- https://www.sdmts.com/getting-around/departures-and-schedules
- Website
- example.com
Bus from Santa Ana to San Ysidro
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a day
- Schedules at
- example.com
- Website
- flixbus.com
Bus from Santa Ana to San Ysidro
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Schedules at
- flixbus.com
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Santa Ana to San Ysidro
- Ave. Duration
- 2h 15m
- Frequency
- Twice daily
- Estimated price
- $18–30
- Schedules at
- flixbus.com
- Website
- greyhound.com
Bus from Santa Ana to San Ysidro
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Schedules at
- greyhound.com
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Santa Ana to San Ysidro
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $16–35
- Website
- https://www.greyhound.com/
- Phone
- +1-800-231-2222
- [email protected]
- Website
- greyhound.com.mx
Bus from Santa Ana to San Diego
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $18–28
- Schedules at
- greyhound.com.mx
- Phone
- +1 619-557-4555
- Website
- sdmts.com
Bus from 12th & Imperial Transit Center to Iris Avenue Transit Center
- Ave. Duration
- 1h 11m
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- https://www.sdmts.com
- Schedules at
- https://www.sdmts.com/getting-around/departures-and-schedules
- One Way - Adult/Youth
- $2–5
Want to know more about travelling around United States
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More Questions & Answers
Tustin to Otay Mesa train services, operated by Amtrak, arrive at San Diego Old Town Transportation Center station.
Yes, the driving distance between Tustin to Otay Mesa is 104 miles. It takes approximately 1h 50m to drive from Tustin to Otay Mesa.
There are 569+ hotels available in Otay Mesa.

















