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How to get fromTwinsburg to Chicagoby train (Amtrak), train, bus, car, tram, plane, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Twinsburg to Chicago by train (Amtrak), train, bus, car, tram, plane, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    7h 24m
    $241–362

  2. Line 32 bus to Akron, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Darrow Rd @ Giant Eagle to RKP Transit Centerbus bus
    2. Fly from Akron (CAK) to Chicago O'Hare International Airport (ORD)plane plane CAK - ORD
    6h 2m
    $43–266

  3. Train, bus (Amtrak)

    1. Take the train from Cleveland Amtrak to Toledotrain train Floridian / ...
    2. Take the bus from Toledo to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    10h 48m

  4. Drive  356.7 mi

    1. Drive from Twinsburg to Chicagocar car 356.7 mi
    6h 2m
    $61–89

  5. Line 32 bus, bus, tram to Cleveland-Hopkins International Airport, fly to Chicago Midway International Airport

    1. Take the bus from E. Aurora Rd @ Grande Village to Southgate Transit Centerbus bus
    2. Take the bus from Southgate Transit Center Stop #4 to Van Aken-Warrensville Sta Stop 2bus bus
    3. Take the tram from Van Aken & Warrensville Stn to E 55Th St Stationtram tram
    4. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane plane CLE - MDW
    5h 44m

  6. Bus

    1. Take the bus from Robert K Pfaff Transit Center - Akron to Chicago Bus Stationbus bus Greyhound US0164
    11h 57m
    $61–111

  7. Line 32 bus, bus, tram to Cleveland-Hopkins International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from E. Aurora Rd @ Grande Village to Southgate Transit Centerbus bus
    2. Take the bus from Southgate Transit Center Stop #4 to Van Aken-Warrensville Sta Stop 2bus bus
    3. Take the tram from Van Aken & Warrensville Stn to E 55Th St Stationtram tram
    4. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago O'Hare International Airport (ORD)plane plane CLE - ORD
    6h 13m

  8. Bus to John Glenn Columbus International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Robert K Pfaff Transit Center - Akron to John Glenn Columbus Intnl Airportbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Chicago Midway International Airport (MDW)plane plane CMH - MDW
    8h 28m
    $86–483

Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW) flights

Calendar23Weekly Planes
Duration2hAverage Duration
Ticket$68Cheapest Price
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Comparing Your Travel Options

Map of how to get from Twinsburg to Chicago.ExpandLaunch map view
  • Distance: 360.4 mi
  • Duration: 7h 24m

What companies run services between Twinsburg, OH, USA and Chicago, IL, USA?

Amtrak operates a train from Cleveland Amtrak to Chicago Union Station 3 times a day. Tickets cost $180–290 and the journey takes 6h 46m. Alternatively, Greyhound USA operates a bus from Robert K Pfaff Transit Center - Akron to Chicago Bus Station twice daily. Tickets cost $70–110 and the journey takes 9h 55m. Flixbus USA also services this route once daily.

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Need to know: Greyhound

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