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How to get fromTwinsburg to Chicagoby train (Amtrak), bus, car, plane, bus (Greyhound, Flixbus), or train

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There are 9 ways to get from Twinsburg to Chicago by train (Amtrak), bus, car, plane, bus (Greyhound, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    7h 24m
    $241–362

  2. Line 104 bus to Akron, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from E. Aurora Rd @ Grande Village to Robert K Pfaff Transit Center - Akronbus bus
    2. Fly from Akron (CAK) to Chicago O'Hare International Airport (ORD)plane plane CAK - ORD
    5h 44m
    $43–266

  3. Bus via Cleveland

    1. Take the bus from Robert K Pfaff Transit Center - Akron to Cleveland Ohio Greyhound Stationbus bus 374 D / ...
    2. Take the bus from Cleveland to Chicagobus bus Bsb 25
    11h 2m
    $44–126

  4. Drive  356.7 mi

    1. Drive from Twinsburg to Chicagocar car 356.7 mi
    6h 2m
    $66–94

  5. Bus

    1. Take the bus from Robert K Pfaff Transit Center - Akron to Chicago Bus Stationbus bus Greyhound US0164
    11h 41m
    $61–101

  6. Line 104 bus, bus to Cleveland-Hopkins International Airport, fly to Chicago Midway International Airport

    1. Take the bus from E. Aurora Rd @ Grande Village to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Cleveland Bus Stationbus bus
    3. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago Midway International Airport (MDW)plane plane CLE - MDW
    5h 47m
    $72–409

  7. Line 104 bus, bus to Cleveland-Hopkins International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from E. Aurora Rd @ Grande Village to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Cleveland Bus Stationbus bus
    3. Fly from Cleveland-Hopkins International Airport (CLE) to Chicago O'Hare International Airport (ORD)plane plane CLE - ORD
    6h 11m
    $372–819

  8. Bus to John Glenn Columbus International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Robert K Pfaff Transit Center - Akron to John Glenn Columbus Intnl Airportbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Chicago Midway International Airport (MDW)plane plane CMH - MDW
    8h 12m
    $76–433

  9. Train to Pittsburgh International Airport, fly to Chicago Midway International Airport

    1. Take the train from Cleveland Amtrak to Pittsburgh Amtrak Stationtrain train
    2. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    8h 37m
    $203–617

Akron (CAK) to Chicago O'Hare International Airport (ORD) flights

Calendar46Weekly Planes
Duration1h 51mAverage Duration
Ticket$39Cheapest Price
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Comparing Your Travel Options

Map of how to get from Twinsburg to Chicago.ExpandLaunch map view
  • Distance: 360.4 mi
  • Duration: 7h 24m

What companies run services between Twinsburg, OH, USA and Chicago, IL, USA?

Amtrak operates a train from Cleveland Amtrak to Chicago Union Station 3 times a day. Tickets cost $180–290 and the journey takes 6h 46m. Alternatively, you can take a bus from Darrow Rd @ Giant Eagle to Chicago via Robert K Pfaff Transit Center - Akron and Cleveland in around 11h 2m.

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