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How to get fromTyrone to Chicagoby bus, plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Tyrone to Chicago by bus, plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Penn State University Park Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from Tyrone Bus Stop to State College Bus Stationbus bus
    2. Fly from Penn State University Park Airport (SCE) to Chicago O'Hare International Airport (ORD)plane plane SCE - ORD
    5h 24m
    $58–306

  2. Train (Amtrak)

    1. Take the train from Tyrone Station to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    14h
    $191–404

  3. Bus via Toledo

    1. Take the bus from Tyrone Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Pittsburgh Intermodal Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Chicago Union Stationbus bus
    15h 2m
    $134–227

  4. Drive 560.9 mi

    1. Drive from Tyrone to Chicagocar car 560.9 mi
    9h 22m
    $103–148

  5. Train to Johnstown-Cambria County Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Tyrone Station to Johnstown Amtrak Stationtrain train
    2. Fly from Johnstown-Cambria County Airport (JST) to Chicago O'Hare International Airport (ORD)plane plane JST - ORD
    5h 16m
    $78–337

  6. Train to Harrisburg International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Tyrone Station to Harrisburgtrain train
    2. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    7h 32m
    $151–734

  7. Train to Pittsburgh International Airport, fly to Chicago Midway International Airport

    1. Take the train from Tyrone Station to Pittsburgh Amtrak Stationtrain train
    2. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    7h 51m
    $103–449

  8. Train to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Tyrone Station to Pittsburgh Amtrak Stationtrain train
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    8h 18m
    $423–1,289

  9. Bus

    1. Take the bus from Tyrone Bus Stop to State College Bus Stationbus bus Greyhound US0400s
    2. Take the bus from State College Regional Airport to Chicago Bus Stationbus bus FlixBus N2641 / ...
    15h 10m
    $106–181

Tyrone to Chicago by train (Amtrak)

Calendar7Weekly Trains
Duration14hAverage Duration
Ticket$191Cheapest Price
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Questions & Answers

Map of how to get from Tyrone to Chicago.ExpandLaunch map view
  • Distance: 576.3 mi
  • Duration: 5h 24m

What companies run services between Tyrone, PA, USA and Chicago, IL, USA?

You can take a train from Tyrone Station to Chicago Union Station via Pittsburgh Amtrak Station in around 14h. Alternatively, you can take a bus from Tyrone Bus Stop to Chicago Union Station via Pittsburgh Intermodal Station and Toledo in around 15h 2m.

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