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How to get fromUyuni to La Serenaby bus, plane, car, or bus (Flixbus)

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There are 7 ways to get from Uyuni to La Serena by bus, plane, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Calama Airport, fly

    best
    1. Take the bus from Uyuni to Terminal de Buses Calamabus bus
    2. Fly from Calama Airport (CJC) to La Florida Airport (LSC)plane plane CJC - LSC
    9h 29m
    $116–317

  2. Bus via Calama

    cheapest
    1. Take the bus from Uyuni to Terminal Rodoviario Calamabus bus Calama
    2. Take the bus from Terminal Rodoviario Calama to Terminal de buses La Serenabus bus Calama
    23h 5m
    $54–107

  3. Bus

    1. Take the bus from Uyuni to Terminal de Buses Calamabus bus Uyuni
    2. Take the bus from Terminal de Buses Calama to Terminal de buses La Serenabus bus Calama
    20h 29m
    $87–138

  4. Drive 1,450.5 km

    1. Drive from Uyuni to La Serenacar car 1,450.5 km
    19h 2m
    $179–259

  5. Fly from Uyuni Airport

    1. Fly from Uyuni Airport (UYU) to La Florida Airport (LSC)plane plane UYU - LSC
    21h 27m
    $216–807

  6. Bus, bus to Antofagasta Airport, fly

    1. Take the bus from Uyuni to Terminal de Buses Calamabus bus
    2. Take the bus from Terminal de Buses Calama to Antofagastabus bus
    3. Fly from Antofagasta Airport (ANF) to La Florida Airport (LSC)plane plane ANF - LSC
    12h 26m
    $125–295

  7. Bus via Uyuni

    1. Take the bus from Uyuni to Terminal de Buses Calamabus bus Uyuni
    2. Take the bus from Terminal de Buses Calama to Terminal de buses La Serenabus bus La Serena
    21h 29m
    $81–133

Uyuni to La Serena by bus

Calendar4Weekly Buses
Duration20h 29mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from Uyuni to La Serena.ExpandLaunch map view
  • Distance: 1,274.1 km
  • Duration: 9h 29m

What companies run services between Uyuni, Potosí, Bolivia and La Serena, Chile?

You can take a bus from Uyuni to Terminal de buses La Serena via Terminal de Buses Calama in around 20h 29m. Alternatively, Boliviana de Aviación, LATAM Chile, and JetSMART fly from Uyuni Airport (UYU) to La Florida Airport (LSC) 4 times a week.

Airlines
Bus operators

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