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How to get fromUyuni to Santa Cruzby plane, bus, car, or shuttle

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There are 6 ways to get from Uyuni to Santa Cruz by plane, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Uyuni Airport to El Calafate

    best
    1. Fly from Uyuni Airport (UYU) to El Calafate (FTE)plane plane UYU - FTE
    20h 43m
    $850,269–2,760,955

  2. Bus to Calama Airport, fly to Puerto Natales

    cheapest
    1. Take the bus from Uyuni to Terminal de Buses Calamabus bus
    2. Fly from Calama Airport (CJC) to Puerto Natales (PNT)plane plane CJC - PNT
    15h 43m
    $336,595–750,059

  3. Bus

    1. Take the bus from Uyuni to Villazónbus bus
    2. Take the bus from Terminal La Quiaca to Terminal de Omnibus de Jujuybus bus
    3. Take the bus from Terminal de Omnibus de Jujuy to Terminal de Ómnibus de Río Gallegosbus bus
    2d 21h
    $421,783–703,783

  4. Drive 4,035.7 km

    1. Drive from Uyuni to Río Gallegoscar car 4,035.7 km
    45h 35m
    $538,437–777,743

  5. Tour, bus

    1. Take a shuttle bus from Uyuni to Saltashuttle bus
    2. Take the bus from Terminal de Salta to Terminal de Omnibus de General Guemesbus bus
    3. Take the bus from Terminal de Omnibus de General Guemes to Esquelbus bus
    4. Take the bus from Terminal De Ómnibus Esquel to Terminal de Ómnibus de Río Gallegosbus bus
    13d 13h
    $768,419–1,131,219

  6. Bus, bus to Gobernador Horacio Guzmán International Airport, fly to El Calafate

    1. Take the bus from Uyuni to Villazónbus bus
    2. Take the bus from Terminal La Quiaca to San Salvador de Jujuybus bus
    3. Fly from Gobernador Horacio Guzmán International Airport (JUJ) to El Calafate (FTE)plane plane JUJ - FTE
    21h 8m
    $466,933–803,433

Uyuni Airport (UYU) to El Calafate (FTE) flights

Calendar5Weekly Planes
Duration23h 25mAverage Duration
Ticket$821,175Cheapest Price
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Questions & Answers

Map of how to get from Uyuni to Santa Cruz.ExpandLaunch map view
  • Distance: 3,372.6 km
  • Duration: 20h 43m

What companies run services between Uyuni, Potosí, Bolivia and Santa Cruz, Argentina?

Boliviana de Aviación and Aerolíneas Argentinas fly from Uyuni Airport (UYU) to El Calafate (FTE) 5 times a week. Alternatively, you can take a bus from Uyuni to Río Gallegos via Villazón, Terminal La Quiaca, Terminal de Omnibus de Jujuy, and Terminal de Ómnibus de Río Gallegos in around 2d 21h.

Airlines
Bus operators

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