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How to get fromUyuni to Santa Cruzby plane, bus, or car

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There are 5 ways to get from Uyuni to Santa Cruz by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Uyuni Airport (UYU) to Viru Viru International Airport (VVI)plane plane UYU - VVI
    4h 20m
    $217–428

  2. Bus via Sucre

    cheapest
    1. Take the bus from Uyuni to Sucrebus bus Uyuni
    2. Take the bus from Sucre to Santa Cruzbus bus Santa Cruz de la Sierra
    20h 4m
    $26–56

  3. Bus

    1. Take the bus from Uyuni to Sucrebus bus Uyuni
    2. Take the bus from Sucre to Santa Cruzbus bus Santa Cruz
    11h 4m

  4. Drive 812.3 km

    1. Drive from Uyuni to Santa Cruz de la Sierracar car 812.3 km
    12h 17m
    $40–57

  5. Bus via Samaipata

    1. Take the bus from Uyuni to Sucrebus bus
    2. Take the bus from Sucre to Samaipatabus bus
    3. Take the bus from Samaipata to Santa Cruzbus bus
    18h 10m
    $61–85

Uyuni Airport (UYU) to Viru Viru International Airport (VVI) flights

Calendar11Weekly Planes
Duration4h 41mAverage Duration
Ticket$217Cheapest Price
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Questions & Answers

Map of how to get from Uyuni to Santa Cruz.ExpandLaunch map view
  • Distance: 521.6 km
  • Duration: 4h 20m

What companies run services between Uyuni, Potosí, Bolivia and Santa Cruz, Bolivia?

Boliviana de Aviación flies from Uyuni Airport (UYU) to Viru Viru International Airport (VVI) twice daily. Alternatively, you can take a bus from Uyuni to Santa Cruz de la Sierra via Sucre and Santa Cruz in around 11h 4m.

Airlines
Bus operators

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