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How to get fromUyuni to Santa Cruzby plane, bus, or car

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There are 5 ways to get from Uyuni to Santa Cruz by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Uyuni Airport, bus

    best
    1. Fly from Uyuni Airport (UYU) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane UYU - SCL
    2. Take the bus from Terminal Sur de Santiago to Santa Cruzbus bus
    18h
    $398–795

  2. Bus via Calama

    cheapest
    1. Take the bus from Uyuni to Terminal Rodoviario Calamabus bus
    2. Take the bus from Terminal Rodoviario Calama to Terminal Alameda - Turbusbus bus
    3. Take the bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruzbus bus
    32h 41m
    $66–125

  3. Bus

    1. Take the bus from Uyuni to Terminal de Buses Calamabus bus
    2. Take the bus from Terminal de Buses Calama to Terminal San Borjabus bus
    3. Take the bus from Terminal Sur de Santiago to Terminal de Buses Santa Cruzbus bus
    31h 1m
    $112–161

  4. Drive 2,070.6 km

    1. Drive from Uyuni to Santa Cruzcar car 2,070.6 km
    26h 27m
    $256–369

  5. Bus to Calama Airport, fly, bus

    1. Take the bus from Uyuni to Terminal de Buses Calamabus bus
    2. Fly from Calama Airport (CJC) to Comodoro Arturo Merino Benítez International Airport (SCL)plane plane CJC - SCL
    3. Take the bus from Terminal Sur de Santiago to Santa Cruzbus bus
    13h 36m
    $118–295

Uyuni Airport (UYU) to Comodoro Arturo Merino Benítez International Airport (SCL) flights

Calendar8Weekly Planes
Duration15h 3mAverage Duration
Ticket$271Cheapest Price
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Questions & Answers

Map of how to get from Uyuni to Santa Cruz.ExpandLaunch map view
  • Distance: 1,707.1 km
  • Duration: 18h

What companies run services between Uyuni, Potosí, Bolivia and Santa Cruz, O'Higgins, Chile?

You can take a bus from Uyuni to Terminal de Buses Santa Cruz via Terminal de Buses Calama, Terminal San Borja, and Terminal Sur de Santiago in around 31h 1m.

Airlines
Bus operators

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