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How to get fromVan Nuys to Otay Mesaby train (Amtrak), bus, car, plane, tram, or bus (Greyhound, Flixbus)

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There are 6 ways to get from Van Nuys to Otay Mesa by train (Amtrak), bus, car, plane, tram, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Van Nuys to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    5h 2m
    $49–111

  2. Drive 152.3 mi

    cheapest
    1. Drive from Van Nuys to Otay Mesacar car 152.3 mi
    2h 45m
    $28–41

  3. Bus

    1. Take the bus from Los Angeles - Pacoima to San Ysidrobus bus San Jose
    6h 41m
    $46–82

  4. Fly from Los Angeles International Airport, tram, line 905 bus

    1. Fly from Los Angeles International Airport (LAX) to San Diego International Airport (SAN)plane plane LAX - SAN
    2. Take the tram from Civic Center Station to Iris Avenue Stationtram tram
    3. Take the bus from Iris Avenue Transit Center to Otay Mesa Rd & Cactus Rdbus bus
    4h 28m
    $174–687

  5. Bus via Los Angeles Union Station

    1. Take the bus from Los Angeles Union Station to San Ysidro Bus Terminalbus bus Greyhound US0831
    6h 55m
    $31–59

  6. Fly from Burbank Bob Hope Airport

    1. Fly from Burbank Bob Hope Airport (BUR) to San Diego International Airport (SAN)plane plane BUR - SAN
    6h 13m
    $272–682

Van Nuys to Otay Mesa by train, tram, and bus (Amtrak)

Calendar42Weekly Services
Duration5h 2mAverage Duration
Ticket$49Cheapest Price
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Questions & Answers

Map of how to get from Van Nuys to Otay Mesa.ExpandLaunch map view
  • Distance: 163.7 mi
  • Duration: 5h 2m

What companies run services between Van Nuys, CA, USA and Otay Mesa, CA, USA?

Amtrak operates a train from Van Nuys to San Diego Old Town Transportation Center every 4 hours. Tickets cost $45–95 and the journey takes 3h 39m. Alternatively, Tufesa operates a bus from Los Angeles - Pacoima to San Ysidro once daily. Tickets cost $40–70 and the journey takes 4h 20m.

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