There are 6 ways to get from Waltham to Indianapolis by train, plane, bus (Flixbus), bus, car, bus (Greyhound), or train (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, fly
best- Take the train from Waltham to North Stationtrain
- Fly from Boston Logan Airport (BOS) to Indianapolis (IND)plane BOS - IND
5h 54m$187–962Bus
cheapest- Take the bus from Newton, MA to Manhattan, NYbus Cambridge
- Take the bus from New York Midtown to Indianapolisbus FlixBus N2642 / ...
21h 5m$149–237Train, bus
- Take the train from Boston to Toledotrain Lake Shore Limited
- Take the bus from Toledo to Indianapolis, INbus Detroit
23h 32m$253–569Drive 900.8 mi
- Drive from Waltham to Indianapoliscar 900.8 mi
16h 17m$165–238Bus via South Station
- Take the bus from South Station to Port Authority Bus Terminalbus Boston
- Take the bus from Port Authority Bus Terminal to Indianapolis Union Stationbus Greyhound US0421
24h 23m$152–344Train (Amtrak)
- Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain Northeast Regional
- Take the train from Ny Moynihan Train Hall At Penn Station to Indianapolistrain Cardinal
29h 42m$332–1,354
Waltham to Indianapolis by bus and train
Questions & Answers
The cheapest way to get from Waltham to Indianapolis is to bus which costs $140 - $240 and takes 21h 5m.
The fastest way to get from Waltham to Indianapolis is to train and fly which takes 5h 54m and costs $180 - $1,000.
No, there is no direct bus from Waltham to Indianapolis. However, there are services departing from Newton, MA and arriving at Indianapolis via New York Midtown. The journey, including transfers, takes approximately 21h 5m.
No, there is no direct train from Waltham to Indianapolis. However, there are services departing from Boston and arriving at Indianapolis via Ny Moynihan Train Hall At Penn Station. The journey, including transfers, takes approximately 29h 42m.
The distance between Waltham and Indianapolis is 849 miles. The road distance is 906 miles.
The best way to get from Waltham to Indianapolis without a car is to bus which takes 21h 5m and costs $140 - $240.
It takes approximately 5h 54m to get from Waltham to Indianapolis, including transfers.
Waltham to Indianapolis bus services, operated by Go Buses, depart from Newton, MA station.
Waltham to Indianapolis train services, operated by Amtrak, depart from Boston station.
The best way to get from Waltham to Indianapolis is to bus which takes 21h 5m and costs $140 - $240. Alternatively, you can train, which costs $330 - $1,400 and takes 29h 42m.
What companies run services between Waltham, MA, USA and Indianapolis, IN, USA?
You can take a bus from Newton, MA to Indianapolis via Manhattan, NY and New York Midtown in around 21h 5m. Alternatively, you can take a bus from Carter St opp Waltham Station to Indianapolis via Lincoln St @ Essex St, Boston, and Ny Moynihan Train Hall At Penn Station in around 29h 42m.
- Website
- delta.com
Flights from Boston Logan Airport to Indianapolis
- Ave. Duration
- 2h 45m
- When
- Every day
- Estimated price
- $110–600
Flights from Boston Logan Airport to Indianapolis via Detroit
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $120–600
- Website
- united.com
Flights from Boston Logan Airport to Indianapolis via Washington Dulles
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $120–650
Flights from Boston Logan Airport to Indianapolis via Newark
- Ave. Duration
- 4h 38m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $110–600
- Website
- aa.com
Flights from Boston Logan Airport to Indianapolis
- Ave. Duration
- 2h 39m
- When
- Every day
- Estimated price
- $110–600
- Website
- southwest.com
Flights from Boston Logan Airport to Indianapolis via Baltimore
- Ave. Duration
- 4h 35m
- When
- Sunday, Monday, Thursday, and Friday
- Estimated price
- $120–650
Flights from Boston Logan Airport to Indianapolis via Chicago Midway
- Ave. Duration
- 4h 40m
- When
- Monday, Thursday, and Friday
- Estimated price
- $130–650
Train from Waltham to North Station
- Ave. Duration
- 27 min
- Frequency
- Hourly
- Estimated price
- $1–8
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $1–8
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Boston to Toledo
- Ave. Duration
- 17h 16m
- Frequency
- Once daily
- Estimated price
- $230–500
- Website
- Amtrak
Train from Boston to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 4h 2m
- Frequency
- Every 3 hours
- Estimated price
- $65–150
- Website
- Amtrak
Train from Ny Moynihan Train Hall At Penn Station to Indianapolis
- Ave. Duration
- 23h 15m
- Frequency
- 3 times a week
- Estimated price
- $280–600
- Website
- Amtrak
Rome2Rio's guide to Amtrak Acela
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Boston to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 3h 49m
- Frequency
- Every 4 hours
- Estimated price
- $50–750
- Schedules at
- Amtrak Acela
- Website
- Amtrak
- Business Class
- $50–490
- First Class
- $200–750
- [email protected]
- Website
- Go Buses
Bus from Newton, MA to Manhattan, NY
- Ave. Duration
- 3h 45m
- Frequency
- Twice daily
- Estimated price
- $35–50
- Website
- Go Buses
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from New York Midtown to Indianapolis
- Ave. Duration
- 16h 15m
- Frequency
- Once daily
- Estimated price
- $110–190
- Schedules at
- Flixbus USA
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Toledo to Indianapolis, IN
- Ave. Duration
- 4h 5m
- Frequency
- Once daily
- Estimated price
- $21–65
- Website
- Barons Bus
- Phone
- 1-800-343-9999
- Website
- Peter Pan
Bus from South Station to Port Authority Bus Terminal
- Ave. Duration
- 4h 35m
- Frequency
- Every 2 hours
- Estimated price
- $40–110
- Website
- Peter Pan
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Port Authority Bus Terminal to Indianapolis Union Station
- Ave. Duration
- 17h 5m
- Frequency
- 3 times a day
- Estimated price
- $110–230
- Website
- Greyhound
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More Questions & Answers
Waltham to Indianapolis bus services, operated by Go Buses, arrive at Manhattan, NY station.
Waltham to Indianapolis train services, operated by Amtrak, arrive at Ny Moynihan Train Hall At Penn Station.
Yes, the driving distance between Waltham to Indianapolis is 906 miles. It takes approximately 16h 17m to drive from Waltham to Indianapolis.
There are 716+ hotels available in Indianapolis.



















