There are 7 ways to get from Waltham to Syracuse by bus (Greyhound, Flixbus), train (Amtrak), car, train, plane, bus (Flixbus), or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Boston to Syracuse Bus Stationbus Greyhound US0171 / ...
8h 8m$47–94Train (Amtrak)
- Take the train from Boston to Syracuse Regional Transportation Centertrain Lake Shore Limited
10h 5m$102–234Drive 301.3 mi
- Drive from Waltham to Syracusecar 301.3 mi
5h 17m$55–80Train, fly to Syracuse Hancock International Airport
- Take the train from Waltham to North Stationtrain
- Fly from Boston Logan Airport (BOS) to Syracuse Hancock International Airport (SYR)plane BOS - SYR
5h 9m$91–568Bus via West Albany
- Take the bus from Boston to Albanybus FlixBus 2691
- Take the bus from Albany to Syracusebus Adt A264
9h 28m$51–89Fly to Rochester, train
- Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane BOS - ROC
- Take the train from Rochester to Syracuse Regional Transportation Centertrain
6h 7m$129–752Fly to Buffalo Niagara International Airport, bus
- Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane BOS - BUF
- Take the bus from Buffalo Niagara International Airport to Syracuse Bus Stationbus
7h 13m$112–600
Waltham to Syracuse by bus
Questions & Answers
The cheapest way to get from Waltham to Syracuse is to bus via West Albany which costs $50 - $90 and takes 9h 28m.
The fastest way to get from Waltham to Syracuse is to train and fly which takes 5h 9m and costs $90 - $600.
No, there is no direct bus from Waltham station to Syracuse station. However, there are services departing from Carter St opp Waltham Station and arriving at Syracuse Bus Station via Boston. The journey, including transfers, takes approximately 8h 8m.
No, there is no direct train from Waltham to Syracuse. However, there are services departing from Boston and arriving at Syracuse Regional Transportation Center via . The journey, including transfers, takes approximately 10h 5m.
The distance between Waltham and Syracuse is 333 miles. The road distance is 303.1 miles.
The best way to get from Waltham to Syracuse without a car is to bus which takes 8h 8m and costs $45 - $95.
It takes approximately 8h 8m to get from Waltham to Syracuse, including transfers.
Waltham to Syracuse bus services, operated by Greyhound USA, depart from Boston station.
Waltham to Syracuse train services, operated by Amtrak, depart from Boston station.
The best way to get from Waltham to Syracuse is to bus which takes 8h 8m and costs $45 - $95. Alternatively, you can train, which costs $100 - $240 and takes 10h 5m.
What companies run services between Waltham, MA, USA and Syracuse, NY, USA?
Greyhound USA operates a bus from Boston to Syracuse Bus Station 4 times a day. Tickets cost $45–90 and the journey takes 6h 25m. Flixbus USA also services this route 6 times a week. Alternatively, Amtrak operates a train from Boston to Syracuse Regional Transportation Center once daily. Tickets cost $100–230 and the journey takes 8h 54m.
- Website
- aa.com
Flights from Boston Logan Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $85–550
Flights from Boston Logan Airport to Rochester
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $85–550
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 46m
- When
- Every day
- Estimated price
- $80–500
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Philadelphia
- Ave. Duration
- 3h 58m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $100–550
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 4h 3m
- When
- Saturday
- Estimated price
- $90–550
- Website
- southwest.com
Flights from Boston Logan Airport to Rochester via Baltimore
- Ave. Duration
- 3h 51m
- When
- Every day
- Estimated price
- $120–650
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 3h 48m
- When
- Tuesday, Wednesday, Saturday, and Sunday
- Estimated price
- $110–600
- Website
- jetblue.com
Flights from Boston Logan Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 16m
- When
- Every day
- Estimated price
- $85–550
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $80–500
- Website
- united.com
Flights from Boston Logan Airport to Rochester via Washington Dulles
- Ave. Duration
- 3h 53m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $120–700
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Newark
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- $90–550
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Washington Dulles
- Ave. Duration
- 4h 3m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $110–600
- Website
- delta.com
Flights from Boston Logan Airport to Rochester via New York La Guardia
- Ave. Duration
- 3h 47m
- When
- Monday to Friday
- Estimated price
- $95–600
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 3h 47m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Boston to Syracuse Regional Transportation Center
- Ave. Duration
- 8h 54m
- Frequency
- Once daily
- Estimated price
- $100–230
- Website
- Amtrak
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a day
- Estimated price
- $25–55
- Website
- Amtrak
Train from Waltham to North Station
- Ave. Duration
- 27 min
- Frequency
- Hourly
- Estimated price
- $1–8
- Website
- Massachusetts Bay Transportation Authority
- Website
- MBTA: World Cup 2026
- Adult
- $1–8
- Phone
- +1 888 842-7245
- Website
- VIA Rail
Train from Rochester to Syracuse Regional Transportation Center
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $21–170
- Website
- VIA Rail
- Escape
- $21–75
- Business
- $50–160
- Business Plus
- $65–170
- Economy
- $24–80
- Economy Plus
- $26–90
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Boston to Syracuse Bus Station
- Ave. Duration
- 6h 25m
- Frequency
- 4 times a day
- Estimated price
- $45–90
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Boston to Syracuse Bus Station
- Ave. Duration
- 6h 30m
- Frequency
- 6 times a week
- Estimated price
- $45–85
- Schedules at
- Flixbus USA
Bus from Boston to Albany
- Ave. Duration
- 3h 50m
- Frequency
- 6 times a week
- Estimated price
- $27–45
- Schedules at
- Flixbus USA
Bus from Albany to Syracuse
- Ave. Duration
- 2h 35m
- Frequency
- 6 times a week
- Estimated price
- $22–40
- Schedules at
- Flixbus USA
Bus from Buffalo Niagara International Airport to Syracuse Bus Station
- Ave. Duration
- 2h 40m
- Frequency
- Every 2 hours
- Estimated price
- $23–40
- Schedules at
- Flixbus USA
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Albany to Syracuse
- Saver
- $26–85
- Flexible
- $50–90
Bus from Buffalo Niagara International Airport to Syracuse Bus Station
- Saver
- $27–85
- Flexible
- $50–90
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More Questions & Answers
Waltham to Syracuse bus services, operated by Greyhound USA, arrive at Syracuse Bus Station.
Waltham to Syracuse train services, operated by Amtrak, arrive at Syracuse Regional Transportation Center station.
Yes, the driving distance between Waltham to Syracuse is 303 miles. It takes approximately 5h 17m to drive from Waltham to Syracuse.
There are 108+ hotels available in Syracuse.

















