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How to get fromWaterloo to St. Louisby train (Amtrak), bus (Amtrak, Flixbus), car, taxi, plane, bus (Amtrak, Greyhound), or train

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There are 7 ways to get from Waterloo to St. Louis by train (Amtrak), bus (Amtrak, Flixbus), car, taxi, plane, bus (Amtrak, Greyhound), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Waterloo Amtrak Station to Chicago Union Stationtrain train Lake Shore Limited / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    9h 7m
    $140–292

  2. Drive 388.1 mi

    cheapest
    1. Drive from Waterloo to St. Louiscar car 388.1 mi
    6h 33m
    $71–103

  3. Bus

    1. Take the bus from Waterloo Amtrak Station to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    10h 25m
    $105–167

  4. Taxi to Fort Wayne International Airport, fly

    1. Take the taxi from Waterloo to Fort Wayne International Airport (FWA)taxi taxi
    2. Fly from Fort Wayne International Airport (FWA) to Lambert–St. Louis International Airport (STL)plane plane FWA - STL
    5h 35m
    $178–591

  5. Bus via Indianapolis

    1. Take the bus from Waterloo Amtrak Station to Elkhart Amtrak Stationbus bus
    2. Take the bus from South Street Station - South Bend to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    11h 49m
    $96–159

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Waterloo Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    7h 6m
    $133–663

  7. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Waterloo Amtrak Station to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    7h 21m
    $325–810

Waterloo to St. Louis by train (Amtrak)

Calendar21Weekly Trains
Duration9h 7mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Waterloo to St. Louis.ExpandLaunch map view
  • Distance: 435 mi
  • Duration: 9h 7m

What companies run services between Waterloo, DeKalb County, IN, USA and St. Louis, MO, USA?

You can take a train from Waterloo Amtrak Station to St. Louis via Chicago Union Station in around 9h 7m. Alternatively, you can take a bus from Waterloo Amtrak Station to St Louis Bus Station via Chicago Union Station and Chicago Bus Station in around 10h 25m.

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