There are 3 ways to get from Waterloo to La Crosse by bus, shuttle, car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, shuttle
best- Take the bus from Waterloo to Des Moinesbus
- Take the bus from Des Moines to Owatonnabus
- Take a shuttle bus from Owatonna, MN to Rochester Sinclair
- Take the bus from Rochester, MN to La Crossebus
12h 1m$103–185Drive 132.5 mi
cheapest- Drive from Waterloo to La Crossecar 132.5 mi
2h 49m$25–35Bus, train
- Take the bus from Waterloo to Chicago Bus Stationbus Greyhound US0154S
- Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain Empire Builder / ...
13h 8m$142–288
Waterloo to La Crosse by bus, foot, and train
Questions & Answers
The cheapest way to get from Waterloo to La Crosse is to drive which costs $24 - $35 and takes 2h 49m.
The fastest way to get from Waterloo to La Crosse is to drive which takes 2h 49m and costs $24 - $35.
The distance between Waterloo and La Crosse is 428 miles. The road distance is 133.2 miles.
The best way to get from Waterloo to La Crosse without a car is to bus and shuttle which takes 12h 1m and costs $100 - $190.
It takes approximately 12h 1m to get from Waterloo to La Crosse, including transfers.
Yes, the driving distance between Waterloo to La Crosse is 133 miles. It takes approximately 2h 49m to drive from Waterloo to La Crosse.
There are 45+ hotels available in La Crosse.
What companies run services between Waterloo, IA, USA and La Crosse, WI, USA?
There is no direct connection from Waterloo to La Crosse. However, you can take the bus to Des Moines, take the bus to Owatonna, walk to Owatonna, MN, take the shuttle to Rochester Sinclair, walk to Rochester, MN, then take the bus to La Crosse. Alternatively, you can drive from Waterloo to La Crosse in around 2h 49m.
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to La Crosse Amtrak Station
- Ave. Duration
- 4h 59m
- Frequency
- 3 times a day
- Estimated price
- $90–190
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Waterloo to Des Moines
- Ave. Duration
- 2h 55m
- Frequency
- 5 times a week
- Estimated price
- $18–35
- Website
- https://www.greyhound.com/
Bus from Waterloo to Chicago Bus Station
- Ave. Duration
- 7h
- Frequency
- 5 times a week
- Estimated price
- $50–100
- Website
- https://www.greyhound.com/
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Owatonna
- Ave. Duration
- 3h 30m
- Frequency
- Twice daily
- Estimated price
- $50–70
- Book at
- https://www.jeffersonlines.com
- Adult
- $50–70
Bus from Rochester, MN to La Crosse
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a day
- Estimated price
- $28–40
- Book at
- https://www.jeffersonlines.com
- Adult
- $28–40
- Phone
- +1 (888) 736-9190
- [email protected]
- Website
- landtoairexpress.com
Shuttle from Owatonna, MN to Rochester Sinclair
- Ave. Duration
- 1h 1m
- Frequency
- Twice daily
- Estimated price
- $6–40
- Schedules at
- landtoairexpress.com
- Adult
- $6–40
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide









