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How to get fromWaterville to Knoxvilleby bus, plane, train, car, taxi, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Waterville to Knoxville by bus, plane, train, car, taxi, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Portland, fly

    best
    1. Take the bus from Waterville to City of Portlandbus bus
    2. Fly from Portland (PWM) to Mcghee Tyson Airport (TYS)plane plane PWM - TYS
    8h 33m
    $297–1,207

  2. Bus

    cheapest
    1. Take the bus from Waterville to Bostonbus bus
    2. Take the bus from Boston to NYC Downtownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    27h 50m
    $163–230

  3. Bus, train

    1. Take the bus from Colby College Museum of Art to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    22h 11m
    $231–977

  4. Drive 1,082.4 mi

    1. Drive from Waterville to Knoxvillecar car 1,082.4 mi
    18h 55m
    $198–286

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Colby College Museum of Art to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Mcghee Tyson Airport (TYS)plane plane BOS - TYS
    7h 39m
    $268–984

  6. Bus to Bangor, fly

    1. Take the bus from Waterville to Bangor Park & Ridebus bus
    2. Fly from Bangor (BGR) to Mcghee Tyson Airport (TYS)plane plane BGR - TYS
    8h 10m
    $381–1,603

  7. Fly from Augusta State Airport

    1. Fly from Augusta State Airport (AUG) to Mcghee Tyson Airport (TYS)plane plane AUG - TYS
    6h 10m
    $278–906

  8. Taxi to Rockland, fly

    1. Take the taxi from Waterville to Rockland (RKD)taxi taxi
    2. Fly from Rockland (RKD) to Mcghee Tyson Airport (TYS)plane plane RKD - TYS
    7h 29m
    $368–1,127

Portland (PWM) to Mcghee Tyson Airport (TYS) flights

Calendar88Weekly Planes
Duration5h 26mAverage Duration
Ticket$219Cheapest Price
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Questions & Answers

Map of how to get from Waterville to Knoxville.ExpandLaunch map view
  • Distance: 1,010.3 mi
  • Duration: 8h 33m

What companies run services between Waterville, ME, USA and Knoxville, TN, USA?

Cape Air, Allegiant Air, and two other airlines fly from Augusta State Airport (AUG) to Mcghee Tyson Airport (TYS) 4 times a day. Alternatively, you can take a vehicle from Waterville to Knoxville Station Hall of Fame via Waterville, Boston, NYC Downtown, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 27h 50m.

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