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How to get fromWayne to St. Louisby bus, plane, train (Amtrak), bus (Flixbus), car, or train

Find Transport to St. Louis

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There are 5 ways to get from Wayne to St. Louis by bus, plane, train (Amtrak), bus (Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Chicago O'Hare International Airport, fly

    best
    1. Take the bus from Elgin Transportation Center - Bus Stop D to Rosemont CTA Station - Bus Stop Dbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    3h 58m
    $352–742

  2. Drive  285.5 mi

    cheapest
    1. Drive from Wayne to St. Louiscar car 285.5 mi
    4h 59m
    $53–76

  3. Train

    1. Take the train from National St to Chicago Union Stationtrain train Md-W
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    7h 12m
    $103–235

  4. Bus

    1. Take the bus from Woodfield Mall to Illinois Terminalbus bus Chicago to Champaign via shopping SB / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus N2521 / ...
    8h 3m
    $132–176

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    5h 18m
    $104–544

Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) flights

Calendar104Weekly Planes
Duration1h 28mAverage Duration
Ticket$52Cheapest Price
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Comparing Your Travel Options

Map of how to get from Wayne to St. Louis.ExpandLaunch map view
  • Distance: 307.4 mi
  • Duration: 3h 58m

What companies run services between Wayne, IL, USA and St. Louis, MO, USA?

You can take a vehicle from Wayne to St. Louis via National St and Chicago Union Station in around 7h 12m. Alternatively, you can take a vehicle from Wayne to St Louis Bus Station via Woodfield Mall, Illinois Terminal, and Champaign Intermodal Trans Ctr in around 8h 3m.

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