Rome2Rio

How to get fromWayne to St. Louisby bus, plane, train (Amtrak), bus (Flixbus), car, or train

Find Transport to St. Louis

See all options

There are 5 ways to get from Wayne to St. Louis by bus, plane, train (Amtrak), bus (Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Chicago O'Hare International Airport, fly

    best
    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    3h 52m
    $302–742

  2. Drive 285.5 mi

    cheapest
    1. Drive from Wayne to St. Louiscar car 285.5 mi
    4h 59m
    $53–76

  3. Train

    1. Take the train from National St to Chicago Union Stationtrain train Md-W
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    7h 12m
    $118–225

  4. Bus

    1. Take the bus from Elgin Transportation Center Bay 4 to Rosemont CTA Stationbus bus 603
    2. Take the bus from O'Hare Multi-Modal Facility to Illinois Terminalbus bus
    3. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus
    10h 21m
    $102–145

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Geneva to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    5h 18m
    $114–594

Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) flights

Calendar109Weekly Planes
Duration1h 28mAverage Duration
Ticket$64Cheapest Price
See schedules

Questions & Answers

Map of how to get from Wayne to St. Louis.ExpandLaunch map view
  • Distance: 307.4 mi
  • Duration: 3h 52m

What companies run services between Wayne, IL, USA and St. Louis, MO, USA?

You can take a vehicle from Wayne to St. Louis via National St and Chicago Union Station in around 7h 12m. Alternatively, you can take a vehicle from Wayne to St Louis Bus Station via Elgin Transportation Center Bay 4, Rosemont CTA Station, O'Hare MMF Bay 8, O'Hare Multi-Modal Facility, Illinois Terminal, and Champaign Intermodal Trans Ctr in around 10h 21m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

More Questions & Answers