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How to get fromWayne to Buffaloby train, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus

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There are 9 ways to get from Wayne to Buffalo by train, plane, train (Amtrak), bus (Greyhound, Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Wayne to Gray 30th St Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    5h 8m
    $110–786

  2. Drive  336.9 mi

    cheapest
    1. Drive from Wayne to Buffalocar car 336.9 mi
    6h 54m
    $62–89

  3. Train (Amtrak)

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    11h 55m
    $263–984

  4. Bus

    1. Take the bus from Philadelphia Bus Station to Newark Penn Stationbus bus Greyhound US0421 / ...
    2. Take the bus from Newark Penn Station to Buffalobus bus FlixBus 2686 / ...
    12h 55m
    $77–139

  5. Fly Philadelphia International Airport to Rochester, bus

    1. Fly from Philadelphia International Airport (PHL) to Rochester (ROC)plane plane PHL - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 28m
    $164–1,000

  6. Train to Baltimore-Washington International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    6h 11m
    $127–1,332

  7. Train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    6h 35m
    $128–652

  8. Train to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    7h 20m
    $136–1,399

  9. Train, bus

    1. Take the train from Paoli Amtrak Station to Harrisburgtrain train
    2. Take the bus from Harrisburg, Pa to Dubois, Pabus bus 731
    3. Take the bus from DuBois to Buffalobus bus
    13h 58m
    $105–279

Wayne to Buffalo by train (Amtrak)

Calendar21Weekly Trains
Duration11h 55mAverage Duration
Ticket$263Cheapest Price
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Comparing Your Travel Options

Map of how to get from Wayne to Buffalo.ExpandLaunch map view
  • Distance: 309.2 mi
  • Duration: 5h 8m

What companies run services between Wayne, PA, USA and Buffalo, NY, USA?

You can take a train from Wayne to Buffalo via 30th Street Station and Ny Moynihan Train Hall At Penn Station in around 11h 55m. Alternatively, you can take a bus from Lancaster Av & Wayne Av to Buffalo via 69th St Transit Center North Terminal, 69th St Transit Center South Terminal, Chestnut St & 12th St, Philadelphia Bus Station, and Newark Penn Station in around 12h 55m.

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