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How to get fromWayne to Chicagoby train, plane, train (Amtrak), bus (Flixbus), car, bus, or bus (Greyhound)

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There are 10 ways to get from Wayne to Chicago by train, plane, train (Amtrak), bus (Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly to Chicago Midway International Airport

    best
    1. Take the train from Wayne to Gray 30th St Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane plane PHL - MDW
    5h 9m
    $157–383

  2. Bus to Lehigh Valley International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Philadelphia 30th St Station to Allentown Transportation Centerbus bus
    2. Fly from Lehigh Valley International Airport (ABE) to Chicago O'Hare International Airport (ORD)plane plane ABE - ORD
    8h 6m
    $86–356

  3. Train via Washington (Amtrak)

    1. Take the train from 30th Street Station to Washington Union Stationtrain train Northeast Regional / ...
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train Floridian
    22h
    $445–1,307

  4. Bus (Flixbus)

    1. Take the bus from Philadelphia Bus Station to Chicago Bus Stationbus bus FlixBus N2642
    22h 44m
    $145–228

  5. Drive  743.4 mi

    1. Drive from Wayne to Chicagocar car 743.4 mi
    12h 10m
    $136–196

  6. Train to Philadelphia International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Wayne to Gray 30th St Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago O'Hare International Airport (ORD)plane plane PHL - ORD
    5h 35m
    $127–233

  7. Train to Baltimore-Washington International Airport, fly to Chicago Midway International Airport

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago Midway International Airport (MDW)plane plane BWI - MDW
    6h 17m
    $149–959

  8. Train to Harrisburg International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Paoli Amtrak Station to Harrisburgtrain train
    2. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    7h 34m
    $101–376

  9. Bus via Baltimore (Greyhound)

    1. Take the bus from Philadelphia Bus Station to Baltimore Greyhound Garagebus bus Greyhound US0305
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    26h 31m
    $163–249

  10. Train (Amtrak)

    1. Take the train from 30th Street Station to Chicago Union Stationtrain train Cardinal
    28h 52m
    $553–904

Wayne to Chicago by train and subway (Amtrak)

Calendar7Weekly Services
Duration22hAverage Duration
Ticket$445Cheapest Price
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Comparing Your Travel Options

Map of how to get from Wayne to Chicago.ExpandLaunch map view
  • Distance: 698.3 mi
  • Duration: 5h 9m

What companies run services between Wayne, PA, USA and Chicago, IL, USA?

You can take a train from Wayne to Chicago Union Station via 30th Street Station, Washington Union Station, Union Station, Red Line Center Platform, Rockville, Red Line Center Platform, and Rockville Amtrak in around 22h. Alternatively, Flixbus USA operates a bus from Philadelphia Bus Station to Chicago Bus Station 3 times a week. Tickets cost $140–220 and the journey takes 20h.

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