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How to get fromWayne to Chicagoby train, plane, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

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There are 8 ways to get from Wayne to Chicago by train, plane, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly to Chicago Midway International Airport

    best
    1. Take the train from Wayne to Gray 30th St Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane plane PHL - MDW
    4h 58m
    $148–411

  2. Train to Philadelphia International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the train from Wayne to Gray 30th St Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago O'Hare International Airport (ORD)plane plane PHL - ORD
    5h 27m
    $93–461

  3. Train via Washington (Amtrak)

    1. Take the train from 30th Street Station to Washington Union Stationtrain train Northeast Regional / ...
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train Floridian
    21h 55m
    $275–1,146

  4. Bus

    1. Take the bus from Philadelphia 30th St Station to Allentown Transportation Centerbus bus Philadelphia / ...
    2. Take the bus from Allentown to Chicago Bus Stationbus bus FlixBus N2640
    22h 48m
    $166–281

  5. Drive 743.4 mi

    1. Drive from Wayne to Chicagocar car 743.4 mi
    12h 11m
    $136–196

  6. Train to Baltimore-Washington International Airport, fly to Chicago Midway International Airport

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago Midway International Airport (MDW)plane plane BWI - MDW
    6h 12m
    $149–958

  7. Bus via Baltimore

    1. Take the bus from Philadelphia to Baltimorebus bus New York
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    23h 57m
    $136–293

  8. Train (Amtrak)

    1. Take the train from 30th Street Station to Chicago Union Stationtrain train Cardinal
    28h 47m
    $343–703

Wayne to Chicago by train and subway (Amtrak)

Calendar7Weekly Services
Duration21h 55mAverage Duration
Ticket$275Cheapest Price
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Questions & Answers

Map of how to get from Wayne to Chicago.ExpandLaunch map view
  • Distance: 698.3 mi
  • Duration: 4h 58m

What companies run services between Wayne, PA, USA and Chicago, IL, USA?

You can take a train from Wayne to Chicago Union Station via 30th Street Station, Washington, Columbus Circle, Union Station, Union Station, Red Line Center Platform, Rockville, Red Line Center Platform, and Rockville Amtrak in around 21h 55m. Alternatively, you can take a bus from Lancaster Av & Wayne Av to Chicago Bus Station via 69th St Transit Center North Terminal, 69th St Transit Center South Terminal, Market St & 30th St, Philadelphia 30th St Station, Allentown Transportation Center, and Allentown in around 22h 48m.

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