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How to get fromWesley Chapel to Key Westby car, plane, bus, ferry, train, shuttle, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Wesley Chapel to Key West by car, plane, bus, ferry, train, shuttle, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Orlando Sanford, fly

    best
    1. Drive from Wesley Chapel to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    3h 40m
    $63–278

  2. Bus, ferry via Marco Island

    1. Take the bus from University of South Florida - 3801 USF Holly Dr to Naples, FLbus bus Tallahassee
    2. Take the ferry from Marco Island, FL to Key West, FLferry ferry Key West
    11h 40m
    $220–250

  3. Train, bus

    1. Take the train from Tampa to Delray Beach Amtraktrain train
    2. Take the train from Delray Beach Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    13h 31m
    $206–306

  4. Drive  398.5 mi

    1. Drive from Wesley Chapel to Key Westcar car 398.5 mi
    8h 12m
    $71–102

  5. Bus to Tampa, fly

    1. Take the bus from SR 54 & Saddlebrook Way to Wiregrass Park and Ridebus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    5h 11m
    $86–226

  6. Bus, shuttle, line 300 bus to Saint Petersburg–Clearwater International Airport, fly

    1. Take the bus from SR 54 & Saddlebrook Way to Wiregrass Park and Ridebus bus
    2. Take a shuttle bus from Gate Gas Station Wesley Chapel to Tampa International Airport - Red Terminalshuttle bus
    3. Take the bus from Tpa Rental Car Facility to Psta 34Th St Complex - Shelter - Dbus bus
    4. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    7h 10m
    $76–292

  7. Bus, ferry

    1. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus FlixBus 2421
    2. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry Fort Myers Beach
    12h 55m
    $186–214

  8. Bus, shuttle

    1. Take the bus from Tampa Bus Station to Miami Airport Stationbus bus FlixBus 2421 / ...
    2. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus To the Keys
    15h 58m
    $222–290

  9. Bus

    1. Take the bus from University of South Florida to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    16h 28m
    $76–120

Wesley Chapel to Key West by bus, tram, and shuttle

Calendar21Weekly Services
Duration15h 58mAverage Duration
Ticket$222Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Wesley Chapel to Key West.ExpandLaunch map view
  • Distance: 391.5 mi
  • Duration: 3h 40m

What companies run services between Wesley Chapel, FL, USA and Key West, FL, USA?

You can take a bus from SR 54 & Saddlebrook Way to N Roosevelt & 3rd Street via Wiregrass Park n Ride, UATC to MSC, University of South Florida, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 16h 28m.

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