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How to get fromWest Chester to Buffaloby bus, plane, bus (Greyhound), train (Amtrak), car, train, or bus (Flixbus, Greyhound)

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There are 9 ways to get from West Chester to Buffalo by bus, plane, bus (Greyhound), train (Amtrak), car, train, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 104 bus to Philadelphia International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Chestnut St & Darlington St to 69th St Transit Centerbus bus
    2. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    5h 21m
    $121–738

  2. Drive 338.7 mi

    cheapest
    1. Drive from West Chester to Buffalocar car 338.7 mi
    6h 46m
    $62–90

  3. Bus via Scranton

    1. Take the bus from Philadelphia 30th St Station to Scrantonbus bus Philadelphia
    2. Take the bus from Scranton Bus Station to Buffalobus bus Greyhound US0205 / ...
    11h 45m
    $96–161

  4. Train (Amtrak)

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    12h 29m
    $166–896

  5. Line 104 bus, train to Baltimore-Washington International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Chestnut St & Darlington St to 69th St Transit Centerbus bus
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    6h 19m
    $122–1,285

  6. Line 104 bus to Philadelphia International Airport, fly to Rochester, bus

    1. Take the bus from Chestnut St & Darlington St to 69th St Transit Centerbus bus
    2. Fly from Philadelphia International Airport (PHL) to Rochester (ROC)plane plane PHL - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h
    $138–753

  7. Line 104 bus, train to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Chestnut St & Darlington St to 69th St Transit Centerbus bus
    2. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    3. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    6h 46m
    $108–580

  8. Train to Ronald Reagan Washington National Airport, fly to Buffalo Niagara International Airport

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Buffalo Niagara International Airport (BUF)plane plane DCA - BUF
    7h 12m
    $172–1,542

  9. Bus

    1. Take the bus from Philadelphia Bus Station to Newark Penn Stationbus bus FlixBus 2601 / ...
    2. Take the bus from Newark Penn Station to Buffalobus bus FlixBus 2686 / ...
    13h 15m
    $78–150

West Chester to Buffalo by bus and subway

Calendar7Weekly Services
Duration11h 45mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from West Chester to Buffalo.ExpandLaunch map view
  • Distance: 325.6 mi
  • Duration: 5h 21m

What companies run services between West Chester, PA, USA and Buffalo, NY, USA?

You can take a bus from Chestnut St & Darlington St to Buffalo via 69th St Transit Center, 69th St Transit Center, Drexel Station at 30th St, Philadelphia 30th St Station, and Scranton Bus Station in around 11h 45m. Alternatively, you can take a bus from Chestnut St & Darlington St to Buffalo via 69th St Transit Center, 69th St Transit Center, Drexel Station at 30th St, 30th Street Station, and Ny Moynihan Train Hall At Penn Station in around 12h 29m.

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