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How to get fromWest Des Moines to Charlestonby plane, bus, train, or car

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There are 5 ways to get from West Des Moines to Charleston by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charleston International Airport

    best
    1. Fly from Des Moines (DSM) to Charleston International Airport (CHS)plane plane DSM - CHS
    6h 10m
    $170–773

  2. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    38h 19m
    $523–1,077

  3. Bus, train via Newark

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Newark Penn Stationbus bus
    3. Take the train from Newark Penn Station to Charleston Amtrak Stationtrain train
    46h 39m
    $427–861

  4. Drive 1,165 mi

    1. Drive from West Des Moines to Charlestoncar car 1,165 mi
    20h 47m
    $213–308

  5. Fly to Hilton Head Airport, drive

    1. Fly from Des Moines (DSM) to Hilton Head Airport (HHH)plane plane DSM - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 31m
    $176–748

Des Moines (DSM) to Charleston International Airport (CHS) flights

Calendar103Weekly Planes
Duration5h 39mAverage Duration
Ticket$150Cheapest Price
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Questions & Answers

Map of how to get from West Des Moines to Charleston.ExpandLaunch map view
  • Distance: 977.1 mi
  • Duration: 6h 10m

What companies run services between West Des Moines, IA, USA and Charleston, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Des Moines (DSM) to Charleston International Airport (CHS) hourly.

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