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How to get fromWest Des Moines to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 9 ways to get from West Des Moines to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS)plane plane DSM - TYS
    4h 45m
    $283–1,191

  2. Fly to Nashville, drive

    cheapest
    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 34m
    $148–671

  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 1m
    $396–615

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 14m
    $556–1,025

  5. Drive 818.5 mi

    1. Drive from West Des Moines to Knoxvillecar car 818.5 mi
    13h 59m
    $150–216

  6. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Des Moines (DSM) to Chattanooga Metropolitan Airport (CHA)plane plane DSM - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 2m
    $266–1,249

  7. Fly to Asheville Regional Airport, drive

    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 22m
    $160–706

  8. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 55m
    $541–1,027

  9. Bus via Indianapolis

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    44h 22m
    $396–650

Des Moines (DSM) to Mcghee Tyson Airport (TYS) flights

Calendar83Weekly Planes
Duration5h 15mAverage Duration
Ticket$216Cheapest Price
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Questions & Answers

Map of how to get from West Des Moines to Knoxville.ExpandLaunch map view
  • Distance: 673 mi
  • Duration: 4h 45m

What companies run services between West Des Moines, IA, USA and Knoxville, TN, USA?

United Airlines, Delta, and American Airlines fly from Des Moines (DSM) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a vehicle from West Des Moines to Knoxville via Des Moines, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 39h 1m.

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