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How to get fromWest Des Moines to Milwaukeeby plane, bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from West Des Moines to Milwaukee by plane, bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to General Mitchell International Airport

    best
    1. Fly from Des Moines (DSM) to General Mitchell International Airport (MKE)plane plane DSM - MKE
    4h 18m
    $97–516

  2. Drive  361.6 mi

    cheapest
    1. Drive from West Des Moines to Milwaukeecar car 361.6 mi
    6h 32m
    $60–87

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    9h 58m
    $127–192

  4. Fly to Chicago O'Hare International Airport, bus

    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2. Take the bus from Chicago to Milwaukee Intermodal Stationbus bus
    4h 19m
    $70–299

  5. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus Greyhound US0150
    10h
    $96–141

  6. Bus via Milwaukee Mitchell Airport

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Bus Station to Milwaukee Mitchell Airportbus bus FlixBus 2548 / ...
    10h 36m
    $98–140

  7. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    11h 9m
    $187–297

Des Moines (DSM) to General Mitchell International Airport (MKE) flights

Calendar146Weekly Planes
Duration5h 14mAverage Duration
Ticket$78Cheapest Price
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Comparing Your Travel Options

Map of how to get from West Des Moines to Milwaukee.ExpandLaunch map view
  • Distance: 323.2 mi
  • Duration: 4h 18m

What companies run services between West Des Moines, IA, USA and Milwaukee, WI, USA?

United Airlines, American Airlines, and two other airlines fly from Des Moines (DSM) to General Mitchell International Airport (MKE) hourly. Alternatively, you can take a vehicle from West Des Moines to Milwaukee Intermodal Station via Des Moines and Chicago Bus Station in around 10h.

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Need to know: Greyhound

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