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How to get fromWest Des Moines to Panama City Beachby plane, bus (Greyhound, Amtrak), bus, train, car, or bus (Greyhound, Flixbus, Amtrak)

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There are 7 ways to get from West Des Moines to Panama City Beach by plane, bus (Greyhound, Amtrak), bus, train, car, or bus (Greyhound, Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP)plane plane DSM - ECP
    5h 4m
    $208–786

  2. Fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Destin–Fort Walton Beach Airport (VPS)plane plane DSM - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 26m
    $158–687

  3. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    29h 54m
    $227–409

  4. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus
    2. Take the train from Champaign-Urbana to New Orleans Union Passenger Terminaltrain train
    3. Take the bus from New Orleans Bus Station to Mobile Bus Stationbus bus
    4. Take the bus from Mobile Bus Station to Panama City Beach Bus Stationbus bus
    33h 36m
    $376–774

  5. Drive 1,067.2 mi

    1. Drive from West Des Moines to Panama City Beachcar car 1,067.2 mi
    20h 5m
    $195–282

  6. Fly to Dothan Regional Airport, drive

    1. Fly from Des Moines (DSM) to Dothan Regional Airport (DHN)plane plane DSM - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama City Beachcar car
    7h
    $165–697

  7. Bus via St. Louis

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    5. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    30h 54m
    $232–439

Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP) flights

Calendar55Weekly Planes
Duration5h 59mAverage Duration
Ticket$144Cheapest Price
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Questions & Answers

Map of how to get from West Des Moines to Panama City Beach.ExpandLaunch map view
  • Distance: 912.9 mi
  • Duration: 5h 4m

What companies run services between West Des Moines, IA, USA and Panama City Beach, FL, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP) every 4 hours. Alternatively, you can take a vehicle from West Des Moines to Panama City Beach via Des Moines, Indianapolis Union Station, Nashville Bus Station, Tallahassee, and Panama City Beach Bus Station in around 29h 54m.

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