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How to get fromWest Lafayette, IN to St. Louisby train, bus, train (Amtrak), car, plane, bus (Greyhound), bus (Amtrak, Greyhound), or shuttle

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There are 7 ways to get from West Lafayette, IN to St. Louis by train, bus, train (Amtrak), car, plane, bus (Greyhound), bus (Amtrak, Greyhound), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Lafayette Amtrak Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    7h 58m
    $60–121

  2. Drive 253 mi

    cheapest
    1. Drive from West Lafayette, IN to St. Louiscar car 253 mi
    4h 55m
    $47–67

  3. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 20m
    $126–271

  4. Fly from Purdue University Airport

    1. Fly from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL)plane plane LAF - STL
    5h 1m
    $79–454

  5. Bus via Indianapolis Airport (IND)

    1. Take the bus from Co-Rec Circle Drive to Indianapolis Airportbus bus Purdue
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    8h 11m
    $66–109

  6. Bus

    1. Take the bus from Lafayette Amtrak Station to Indianapolis Union Stationbus bus Chicago
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    8h 25m
    $50–116

  7. Shuttle to Indianapolis, fly

    1. Take a shuttle bus from McCutcheon Hall on McCutcheon to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)plane plane IND - STL
    6h 48m
    $113–636

West Lafayette, IN to St. Louis by bus and train

Calendar3Weekly Services
Duration7h 58mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

Map of how to get from West Lafayette, IN to St. Louis.ExpandLaunch map view
  • Distance: 319.3 mi
  • Duration: 7h 58m

What companies run services between West Lafayette, IN, USA and St. Louis, MO, USA?

You can take a bus from Purdue West on Mitch Daniels Blvd to St. Louis via Columbia St & 4th St, Lafayette Amtrak Station, and Chicago Union Station in around 10h 20m. Alternatively, United Airlines flies from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL) once daily.

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