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How to get fromWest Lafayette to Des Moinesby bus (Flixbus, Greyhound), train, bus, car, plane, bus (Amtrak), or shuttle

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There are 9 ways to get from West Lafayette to Des Moines by bus (Flixbus, Greyhound), train, bus, car, plane, bus (Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Lafayette Bus Stop to Chicago Bus Stationbus bus FlixBus 2511 / ...
    2. Take the bus from Chicago to Des Moinesbus bus Btw 1205 / ...
    10h 25m

  2. Drive 407.8 mi

    cheapest
    1. Drive from West Lafayette to Des Moinescar car 407.8 mi
    7h 37m
    $75–108

  3. Train, bus via Galesburg

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    12h 55m
    $119–250

  4. Fly from Purdue University Airport

    1. Fly from Purdue University Airport (LAF) to Des Moines (DSM)plane plane LAF - DSM
    7h 19m
    $108–572

  5. Bus via Chicago

    1. Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus bus
    2. Take the bus from Chicago to Des Moinesbus bus Btw 1205 / ...
    10h 39m

  6. Train, bus

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train Cardinal
    2. Take the bus from Chicago to Des Moinesbus bus Btw 1205 / ...
    11h 43m

  7. Shuttle to Indianapolis, fly

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Des Moines (DSM)plane plane IND - DSM
    6h 11m
    $152–754

  8. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Pmu to ORD Airportbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    4h 44m
    $148–572

  9. Bus to Chicago Midway International Airport, fly

    1. Take the bus from Lafayette Bus Stop to Chicagobus bus
    2. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    5h 35m
    $138–714

Purdue University Airport (LAF) to Des Moines (DSM) flights

Calendar25Weekly Planes
Duration7h 40mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

Map of how to get from West Lafayette to Des Moines.ExpandLaunch map view
  • Distance: 464.1 mi
  • Duration: 10h 25m

What companies run services between West Lafayette, IN, USA and Des Moines, IA, USA?

You can take a bus from Lafayette Bus Stop to Des Moines via Chicago in around 10h 25m. Alternatively, United Airlines flies from Purdue University Airport (LAF) to Des Moines (DSM) 4 times a day.

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