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How to get fromWest Lafayette to Great Smoky Mountainsby shuttle, plane, car, bus, or train

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There are 11 ways to get from West Lafayette to Great Smoky Mountains by shuttle, plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Indianapolis, fly to Mcghee Tyson Airport, drive

    best
    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Mcghee Tyson Airport (TYS)plane plane IND - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 36m
    $145–849

  2. Drive 466.9 mi

    cheapest
    1. Drive from West Lafayette to Great Smoky Mountainscar car 466.9 mi
    9h 1m
    $86–124

  3. Bus, drive

    1. Take the bus from Lafayette Bus Stop to Columbusbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    21h 22m
    $133–249

  4. Train, bus, drive

    1. Take the train from Lafayette Amtrak Station to Charlottesvilletrain train
    2. Take the train from Charlottesville to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    28h 30m
    $300–635

  5. Fly Purdue University Airport to Mcghee Tyson Airport, drive

    1. Fly from Purdue University Airport (LAF) to Mcghee Tyson Airport (TYS)plane plane LAF - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 31m
    $141–767

  6. Bus to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 7m
    $176–737

  7. Bus to Chicago O'Hare International Airport, fly to Asheville Regional Airport, drive

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    7h 27m
    $130–433

  8. Shuttle to Indianapolis, fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane IND - ATL
    3. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    8h 14m
    $200–638

  9. Bus to Chicago Midway International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Lafayette Bus Stop to Chicagobus bus
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    7h 33m
    $161–858

  10. Shuttle to Indianapolis, fly to Nashville, drive

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Nashville (BNA)plane plane IND - BNA
    3. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    8h 23m
    $365–1,198

  11. Train, bus, drive via Ironville

    1. Take the train from Lafayette Amtrak Station to Ashland Amtrak Stationtrain train
    2. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    22h 27m
    $186–376

Indianapolis (IND) to Mcghee Tyson Airport (TYS) flights

Calendar145Weekly Planes
Duration4h 43mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

Map of how to get from West Lafayette to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 426.7 mi
  • Duration: 7h 36m

What companies run services between West Lafayette, IN, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from West Lafayette to Great Smoky Mountains. However, you can take the shuttle to Indianapolis Airport, walk to Indianapolis (IND) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Lafayette Bus Stop to Great Smoky Mountains via Columbus, S 3Rd St & E Town St, E Livingston Ave & Macon Aly, Columbus, Winston Salem(Trans Center), and Asheville, NC in around 21h 22m.

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