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How to get fromWest Lafayette to Kirksvilleby bus, train, car, plane, train (Amtrak), or shuttle

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There are 9 ways to get from West Lafayette to Kirksville by bus, train, car, plane, train (Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train (Amtrak)

    best
    1. Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus bus
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    8h 29m
    $159–299

  2. Drive 361.6 mi

    cheapest
    1. Drive from West Lafayette to Kirksvillecar car 361.6 mi
    6h 44m
    $66–96

  3. Bus, train via Galesburg

    1. Take the bus from Lafayette Bus Stop to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train
    10h 55m
    $130–238

  4. Bus to Chicago O'Hare International Airport, fly to Kirksville Regional Airport

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK)plane plane ORD - IRK
    5h 12m
    $156–306

  5. Bus, train via Chicago

    1. Take the bus from Lafayette Bus Stop to Chicago Bus Stationbus bus FlixBus 2511 / ...
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    8h 33m
    $153–289

  6. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    9h 33m
    $173–334

  7. Bus to Chicago O'Hare International Airport, fly to Burlington Municipal Airport, drive

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Burlington Municipal Airport (BRL)plane plane ORD - BRL
    3. Drive from Burlington Municipal Airport (BRL) to Kirksvillecar car
    7h 39m
    $132–236

  8. Fly Purdue University Airport to Kirksville Regional Airport

    1. Fly from Purdue University Airport (LAF) to Kirksville Regional Airport (IRK)plane plane LAF - IRK
    13h 4m
    $156–506

  9. Shuttle to Indianapolis, fly to Kirksville Regional Airport

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Kirksville Regional Airport (IRK)plane plane IND - IRK
    7h 23m
    $170–678

Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK) flights

Calendar7Weekly Planes
Duration1h 30mAverage Duration
Ticket$68Cheapest Price
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Questions & Answers

Map of how to get from West Lafayette to Kirksville.ExpandLaunch map view
  • Distance: 431.9 mi
  • Duration: 8h 29m

What companies run services between West Lafayette, IN, USA and Kirksville, MO, USA?

You can take a train from Lafayette Amtrak Station to Kirksville via Chicago Union Station and La Plata Station in around 9h 33m. Alternatively, United Airlines and Corporate Flight Management Inc fly from Purdue University Airport (LAF) to Kirksville Regional Airport (IRK) once daily.

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