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How to get fromWest Lafayette to Knoxvilleby shuttle, plane, bus (Flixbus), train, bus, or car

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There are 9 ways to get from West Lafayette to Knoxville by shuttle, plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Indianapolis, fly to Mcghee Tyson Airport

    best
    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Mcghee Tyson Airport (TYS)plane plane IND - TYS
    6h 2m
    $190–853

  2. Drive 410.4 mi

    cheapest
    1. Drive from West Lafayette to Knoxvillecar car 410.4 mi
    7h 12m
    $75–109

  3. Bus

    1. Take the bus from Lafayette Bus Stop to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    35h 5m
    $238–344

  4. Train, bus via Farragut

    1. Take the train from Lafayette Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Cardinal
    2. Take the bus from New York to Knoxvillebus bus Nyc
    38h
    $508–919

  5. Fly Purdue University Airport to Mcghee Tyson Airport

    1. Fly from Purdue University Airport (LAF) to Mcghee Tyson Airport (TYS)plane plane LAF - TYS
    5h 56m
    $176–721

  6. Bus to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    5h 33m
    $211–741

  7. Shuttle to Indianapolis, fly to Nashville, drive

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Nashville (BNA)plane plane IND - BNA
    3. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 34m
    $355–1,183

  8. Bus to Chicago Midway International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Lafayette Bus Stop to Chicagobus bus
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    5h 58m
    $196–862

  9. Train, bus

    1. Take the train from Lafayette Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Cardinal
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    38h 4m
    $463–829

Indianapolis (IND) to Mcghee Tyson Airport (TYS) flights

Calendar144Weekly Planes
Duration4h 43mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from West Lafayette to Knoxville.ExpandLaunch map view
  • Distance: 380.3 mi
  • Duration: 6h 2m

What companies run services between West Lafayette, IN, USA and Knoxville, TN, USA?

You can take a bus from Lafayette Bus Stop to Knoxville Station Hall of Fame via New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 35h 5m. Alternatively, United Airlines flies from Purdue University Airport (LAF) to Mcghee Tyson Airport (TYS) 3 times a day.

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