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How to get fromWest Lafayette to Mayo Clinicby bus, train, car, plane, or shuttle

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There are 10 ways to get from West Lafayette to Mayo Clinic by bus, train, car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    11h 15m
    $129–196

  2. Fly Purdue University Airport to Rochester

    cheapest
    1. Fly from Purdue University Airport (LAF) to Rochester (RST)plane plane LAF - RST
    7h 35m
    $52–361

  3. Train, bus

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    14h 28m
    $196–389

  4. Drive 467.1 mi

    1. Drive from West Lafayette to Mayo Cliniccar car 467.1 mi
    7h 53m
    $86–124

  5. Bus, train

    1. Take the bus from Lafayette Bus Stop to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    11h 41m
    $115–194

  6. Shuttle, bus

    1. Take a shuttle bus from State Street Bus Stop, Lafayette IN to Multi-Modal Facilityshuttle bus
    2. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    12h 51m
    $105–184

  7. Train, bus via Madison

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    13h 30m
    $113–209

  8. Bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    6h 9m
    $97–401

  9. Shuttle to Indianapolis, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Minneapolis–Saint Paul International Airport (MSP)plane plane IND - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 16m
    $567–1,185

  10. Bus to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Lafayette Bus Stop to Chicagobus bus
    2. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 36m
    $148–575

West Lafayette to Mayo Clinic by train, bus, and foot

Calendar3Weekly Services
Duration14h 28mAverage Duration
Ticket$196Cheapest Price
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Questions & Answers

Map of how to get from West Lafayette to Mayo Clinic.ExpandLaunch map view
  • Distance: 473.9 mi
  • Duration: 11h 15m

What companies run services between West Lafayette, IN, USA and Mayo Clinic, MN, USA?

You can take a bus from Purdue Memorial Union to Mayo Clinic via Multi-Modal/Rental Car Facility, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 11h 15m. Alternatively, United Airlines and American Airlines fly from Purdue University Airport (LAF) to Rochester (RST) 3 times a day.

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