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How to get fromWest Lafayette to Saint Charlesby bus (Greyhound), bus, train, car, plane, bus (Amtrak, Greyhound), train (Amtrak), or shuttle

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There are 9 ways to get from West Lafayette to Saint Charles by bus (Greyhound), bus, train, car, plane, bus (Amtrak, Greyhound), train (Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Lafayette Bus Stop to Indianapolis Union Stationbus bus Greyhound US0120S / ...
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    8h 23m
    $47–90

  2. Bus, train

    1. Take the bus from Lafayette Bus Stop to Chicago Bus Stationbus bus FlixBus 2511 / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    9h 35m
    $112–229

  3. Drive 267.3 mi

    1. Drive from West Lafayette to Saint Charlescar car 267.3 mi
    5h 13m
    $49–71

  4. Fly from Purdue University Airport

    1. Fly from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL)plane plane LAF - STL
    6h 28m
    $80–465

  5. Bus via Lafayette Amtrak Station

    1. Take the bus from Lafayette Amtrak Station to Indianapolis Union Stationbus bus Chicago
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    8h 40m
    $53–116

  6. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 35m
    $133–273

  7. Shuttle to Indianapolis, fly

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)plane plane IND - STL
    6h 52m
    $114–637

  8. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 51m
    $330–775

  9. Bus to Chicago Midway International Airport, fly

    1. Take the bus from Lafayette Bus Stop to Chicagobus bus
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    6h 31m
    $100–597

West Lafayette to Saint Charles by bus (Greyhound)

Calendar21Weekly Buses
Duration8h 23mAverage Duration
Ticket$47Cheapest Price
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Questions & Answers

Map of how to get from West Lafayette to Saint Charles.ExpandLaunch map view
  • Distance: 328.3 mi
  • Duration: 8h 23m

What companies run services between West Lafayette, IN, USA and Saint Charles, MO, USA?

You can take a bus from Lafayette Bus Stop to 4375 Rider Trail North Sb via Indianapolis Union Station, St Louis Bus Station, Civic Center Transit Center, and North Hanley Transit Center in around 8h 23m. Alternatively, United Airlines flies from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL) once daily.

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