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How to get fromWest Lafayette to St. Louisby bus (Greyhound), bus, train, car, plane, bus (Amtrak, Greyhound), train (Amtrak), or shuttle

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There are 10 ways to get from West Lafayette to St. Louis by bus (Greyhound), bus, train, car, plane, bus (Amtrak, Greyhound), train (Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Indianapolis

    best
    1. Take the bus from Lafayette Bus Stop to Indianapolisbus bus FlixBus 2515 / ...
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    6h 24m

  2. Drive 253.2 mi

    cheapest
    1. Drive from West Lafayette to St. Louiscar car 253.2 mi
    4h 56m
    $47–67

  3. Bus, train

    1. Take the bus from Lafayette Bus Stop to Chicago Bus Stationbus bus FlixBus 2511 / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    8h 10m
    $109–226

  4. Fly from Purdue University Airport

    1. Fly from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL)plane plane LAF - STL
    6h 4m
    $79–464

  5. Bus

    1. Take the bus from Lafayette Amtrak Station to Indianapolis Union Stationbus bus Chicago
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    7h 15m
    $49–117

  6. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    9h 10m
    $129–269

  7. Shuttle to Indianapolis, fly

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)plane plane IND - STL
    6h 28m
    $118–636

  8. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Pmu to ORD Airportbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 4m
    $329–774

  9. Bus to Chicago Midway International Airport, fly

    1. Take the bus from Lafayette Bus Stop to Chicagobus bus
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    5h 56m
    $105–597

  10. Bus, bus to General Mitchell International Airport, fly

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Take the bus from Multi-Modal/Rental Car Facility to Mitchell Airportbus bus
    3. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    6h 58m
    $574–962

Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL) flights

Calendar9Weekly Planes
Duration4h 11mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

Map of how to get from West Lafayette to St. Louis.ExpandLaunch map view
  • Distance: 306 mi
  • Duration: 6h 24m

What companies run services between West Lafayette, IN, USA and St. Louis, MO, USA?

You can take a bus from Lafayette Bus Stop to St Louis Bus Station via Indianapolis and Indianapolis Union Station in around 6h 24m. Alternatively, United Airlines flies from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL) once daily.

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