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How to get fromWest Lafayette to St. Louisby bus (Greyhound), bus, train, car, plane, bus (Amtrak, Greyhound), train (Amtrak), or shuttle

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There are 9 ways to get from West Lafayette to St. Louis by bus (Greyhound), bus, train, car, plane, bus (Amtrak, Greyhound), train (Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Lafayette Bus Stop to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    6h 10m
    $51–82

  2. Drive  253.2 mi

    cheapest
    1. Drive from West Lafayette to St. Louiscar car 253.2 mi
    4h 56m
    $44–63

  3. Bus, train

    1. Take the bus from Lafayette Bus Stop to Chicago Bus Stationbus bus FlixBus 2515 / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    8h 10m
    $170–272

  4. Fly from Purdue University Airport

    1. Fly from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL)plane plane LAF - STL
    6h 12m
    $74–464

  5. Bus via Lafayette Amtrak Station

    1. Take the bus from Lafayette Amtrak Station to Indianapolis Union Stationbus bus Chicago
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    6h 15m
    $54–107

  6. Train (Amtrak)

    1. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    9h 10m
    $216–342

  7. Shuttle to Indianapolis, fly

    1. Take a shuttle bus from Purdue Mem Union - State Street to Indianapolis Airportshuttle bus
    2. Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)plane plane IND - STL
    7h 3m
    $108–636

  8. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Purdue Memorial Union to O'Hare Multi-Modal Facilitybus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 32m
    $379–774

  9. Bus to Chicago Midway International Airport, fly

    1. Take the bus from Lafayette Bus Stop to Chicago Bus Stationbus bus
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    6h 12m
    $110–640

West Lafayette to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration6h 10mAverage Duration
Ticket$51Cheapest Price
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Comparing Your Travel Options

Map of how to get from West Lafayette to St. Louis.ExpandLaunch map view
  • Distance: 305.2 mi
  • Duration: 6h 10m

What companies run services between West Lafayette, IN, USA and St. Louis, MO, USA?

You can take a bus from Lafayette Bus Stop to St Louis Bus Station via Indianapolis Union Station in around 6h 10m. Alternatively, United Airlines flies from Purdue University Airport (LAF) to Lambert–St. Louis International Airport (STL) twice daily.

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Need to know: Greyhound

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