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How to get fromWest Seneca to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), or car

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There are 7 ways to get from West Seneca to Chicago by bus, plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 15 bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Seneca Street & Mt. Vernon Avenue to North Division Street & Oak Streetbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    4h 57m
    $169–345

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    13h 1m
    $97–152

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    10h 45m
    $316–481

  4. Drive  528.5 mi

    1. Drive from West Seneca to Chicagocar car 528.5 mi
    8h 57m
    $97–140

  5. Fly Buffalo Niagara International Airport to Chicago O'Hare International Airport

    1. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    5h 22m
    $179–335

  6. Bus to Rochester, fly to Chicago Midway International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 32m
    $118–600

  7. Bus to Rochester, fly to Chicago O'Hare International Airport

    1. Take the bus from Buffalo to Rochester Bus Stopbus bus
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    6h 56m
    $98–440

West Seneca to Chicago by bus (Greyhound)

Calendar14Weekly Buses
Duration13h 1mAverage Duration
Ticket$97Cheapest Price
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Comparing Your Travel Options

Map of how to get from West Seneca to Chicago.ExpandLaunch map view
  • Distance: 493.5 mi
  • Duration: 4h 57m

What companies run services between West Seneca, NY, USA and Chicago, IL, USA?

Amtrak operates a train from Buffalo Depew Station to Chicago Union Station twice daily. Tickets cost $290–450 and the journey takes 10h 33m. Alternatively, you can take a bus from Seneca Street & Mt. Vernon Avenue to Chicago Bus Station via North Division Street & Oak Street, Buffalo, and Cleveland Bus Station in around 13h 1m.

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