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How to get fromWest Virginia to St. Louisby bus, plane, train, bus (Greyhound), car, subway, or train (Amtrak)

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There are 9 ways to get from West Virginia to St. Louis by bus, plane, train, bus (Greyhound), car, subway, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly

    best
    1. Take the bus from MountainLair to Pittsburgh Airport PITbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    5h 28m
    $116–633

  2. Drive 504.4 mi

    cheapest
    1. Drive from Charleston to St. Louiscar car 504.4 mi
    8h 18m
    $92–133

  3. Train, bus

    1. Take the train from Charleston Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    13h 41m
    $145–296

  4. Bus

    1. Take the bus from Charleston, WV to Cambridgebus bus Charleston
    2. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus Greyhound US0421
    14h 20m
    $93–198

  5. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from Martinsburg W Va Marc to ROCKVILLE MARC ebtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    6h 12m
    $187–427

  6. Train, train to Baltimore-Washington International Airport, fly

    1. Take the train from Martinsburg W Va Marc to Washington Union Stationtrain train
    2. Take the train from Washington Union Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    6h 54m
    $159–1,301

  7. Train, subway to Washington Dulles International Airport, fly

    1. Take the train from Martinsburg W Va Marc to ROCKVILLE MARC ebtrain train
    2. Take the subway from Farragut West, Blue/Orange/Silver Line Track 2 Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    3. Fly from Washington Dulles International Airport (IAD) to Lambert–St. Louis International Airport (STL)plane plane IAD - STL
    6h 48m
    $206–1,046

  8. Bus to John Glenn Columbus International Airport, fly

    1. Take the bus from Wheeling Bus Stop to Columbusbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    6h 48m
    $832–953

  9. Train (Amtrak)

    1. Take the train from Charleston Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    20h 2m
    $265–539

West Virginia to St. Louis by train and bus

Calendar3Weekly Services
Duration13h 41mAverage Duration
Ticket$145Cheapest Price
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Questions & Answers

Map of how to get from West Virginia to St. Louis.ExpandLaunch map view
  • Distance: 644.9 mi
  • Duration: 5h 28m

What companies run services between West Virginia, USA and St. Louis, MO, USA?

You can take a bus from Charleston, WV to St Louis Bus Station via Cambridge and Cambridge, OH in around 14h 20m. Alternatively, you can take a train from Charleston Station to St. Louis via Chicago Union Station in around 20h 2m.

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