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How to get fromWheaton to Mayo Clinicby bus, plane, train, or car

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There are 8 ways to get from Wheaton to Mayo Clinic by bus, plane, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 90 bus to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the bus from Harlem/Lake Green Line Station to Harlem Blue Line Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 20m
    $50–343

  2. Train, bus via Milwaukee

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    10h 20m
    $105–169

  3. Train, bus

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    12h 7m
    $166–319

  4. Drive 328.4 mi

    1. Drive from Wheaton to Mayo Cliniccar car 328.4 mi
    5h 35m
    $60–87

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 3m
    $281–515

  6. Train to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 20m
    $134–543

  7. Train, bus #2

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    11h 9m
    $83–139

  8. Train, bus #3

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Take the bus from Chicago Bus Station to Madisonbus bus
    3. Take the bus from Madison to Rochesterbus bus
    11h 22m
    $83–134

Wheaton to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration10h 20mAverage Duration
Ticket$105Cheapest Price
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Questions & Answers

Map of how to get from Wheaton to Mayo Clinic.ExpandLaunch map view
  • Distance: 306.2 mi
  • Duration: 5h 20m

What companies run services between Wheaton, IL, USA and Mayo Clinic, MN, USA?

There is no direct connection from Wheaton to Mayo Clinic. However, you can take the train to Oak Park, walk to Harlem/Lake Green Line Station, take the line 90 bus to Harlem Blue Line Station, walk to Harlem-O'Hare, take the subway to O'Hare, walk to Chicago O'Hare International Airport (ORD) airport, fly to Rochester (RST), walk to Rochester - Airport, take the shuttle to Rochester, then walk to Mayo Clinic. Alternatively, you can take a train from Wheaton to Mayo Clinic via Chicago OTC, Madison & Canal, Clinton & Jackson, Chicago Union Station, Milwaukee, Milwaukee, and Rochester in around 10h 20m.

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