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How to get fromWheaton to St. Louisby train (Amtrak), bus (Flixbus), car, train, bus, or plane

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There are 5 ways to get from Wheaton to St. Louis by train (Amtrak), bus (Flixbus), car, train, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Wheaton to Chicago OTCtrain train Up-W
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 49m
    $98–199

  2. Drive 280 mi

    cheapest
    1. Drive from Wheaton to St. Louiscar car 280 mi
    4h 47m
    $52–74

  3. Bus

    1. Take the bus from Oakbrook Mall to Illinois Terminalbus bus Chicago to Champaign via shopping SB / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus N2521 / ...
    8h 40m
    $76–113

  4. Train, line 90 bus to Chicago O'Hare International Airport, fly

    1. Take the train from Wheaton to Oak Parktrain train
    2. Take the bus from Harlem/Lake Green Line Station to Harlem Blue Line Stationbus bus
    3. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    4h 37m
    $282–716

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4h 50m
    $90–564

Wheaton to St. Louis by train and bus

Calendar38Weekly Services
Duration6h 49mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from Wheaton to St. Louis.ExpandLaunch map view
  • Distance: 306.4 mi
  • Duration: 6h 49m

What companies run services between Wheaton, IL, USA and St. Louis, MO, USA?

You can take a train from Wheaton to St. Louis via Chicago OTC, Madison & Canal, Clinton & Jackson, and Chicago Union Station in around 6h 49m. Alternatively, you can take a bus from West St & Indiana St to St Louis Bus Station via Oakbrook Mall, Illinois Terminal, and Champaign Intermodal Trans Ctr in around 8h 40m.

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