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How to get fromWheaton to St. Louisby train (Amtrak), bus (Flixbus), car, train, or plane

Find Transport to St. Louis

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There are 6 ways to get from Wheaton to St. Louis by train (Amtrak), bus (Flixbus), car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Wheaton to Chicago OTCtrain train Up-W
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 50m
    $158–249

  2. Drive  280 mi

    cheapest
    1. Drive from Wheaton to St. Louiscar car 280 mi
    4h 47m
    $52–74

  3. Bus

    1. Take the bus from Oakbrook Mall to Illinois Terminalbus bus Chicago to Champaign via shopping SB / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus N2521 / ...
    8h 35m
    $75–108

  4. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 1m
    $280–714

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4h 50m
    $80–514

  6. Train, train to General Mitchell International Airport, fly

    1. Take the train from Wheaton to Chicago OTCtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    7h 5m
    $538–951

Wheaton to St. Louis by train and bus

Calendar38Weekly Services
Duration6h 50mAverage Duration
Ticket$158Cheapest Price
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Comparing Your Travel Options

Map of how to get from Wheaton to St. Louis.ExpandLaunch map view
  • Distance: 306.4 mi
  • Duration: 6h 50m

What companies run services between Wheaton, IL, USA and St. Louis, MO, USA?

You can take a train from Wheaton to St. Louis via Chicago OTC, Madison & Canal, Clinton & Jackson, and Chicago Union Station in around 6h 50m. Alternatively, you can take a bus from West St & Indiana St to St Louis Bus Station via Oakbrook Mall, Illinois Terminal, and Champaign Intermodal Trans Ctr in around 8h 35m.

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