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How to get fromWheeling to Knoxvilleby plane, bus (Flixbus), train, bus, or car

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There are 9 ways to get from Wheeling to Knoxville by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    3h 35m
    $159–674

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 37m
    $86–379

  3. Bus

    1. Take the bus from Chicago Bus Station to New York Midtownbus bus FlixBus N2641 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    35h 21m
    $328–501

  4. Train, bus

    1. Take the train from Wheeling to Chicago Union Stationtrain train Ncs
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    35h 40m
    $488–909

  5. Drive 550.4 mi

    1. Drive from Wheeling to Knoxvillecar car 550.4 mi
    9h 45m
    $101–146

  6. Fly Chicago O'Hare International Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Chattanooga Metropolitan Airport (CHA)plane plane ORD - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 3m
    $132–682

  7. Train to Chicago Midway International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Wheeling to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    4h 40m
    $182–831

  8. Train, bus via Ossining

    1. Take the train from Wheeling to Chicago Union Stationtrain train Ncs
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 10m
    $443–836

  9. Train, bus #2

    1. Take the train from Wheeling to Chicago Union Stationtrain train Ncs
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    39h 50m
    $254–391

Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) flights

Calendar75Weekly Planes
Duration2h 58mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from Wheeling to Knoxville.ExpandLaunch map view
  • Distance: 501.5 mi
  • Duration: 3h 35m

What companies run services between Wheeling, IL, USA and Knoxville, TN, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a bus from Dundee/Northgate to Knoxville via Des Plaines Metra Station, Cumberland CTA Station, Chicago, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 35h 21m.

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