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How to get fromWheeling to Chicagoby bus, plane, bus (Greyhound), train, car, or bus (Flixbus)

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There are 8 ways to get from Wheeling to Chicago by bus, plane, bus (Greyhound), train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, bus to Pittsburgh International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Wheeling Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Seventh Ave + Smithfield St to Pittsburgh International Airportbus bus
    3. Fly from Pittsburgh International Airport (PIT) to Chicago Midway International Airport (MDW)plane plane PIT - MDW
    6h 2m

  2. Bus via Columbus

    cheapest
    1. Take the bus from Wheeling Bus Stop to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus to Chicagobus bus Bsb 21 / ...
    11h 10m
    $53–114

  3. Bus, train

    1. Take the bus from Wheeling Bus Stop to Pittsburgh Intermodal Stationbus bus Greyhound US0421
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    12h 1m
    $269–425

  4. Drive  428.1 mi

    1. Drive from Wheeling to Chicagocar car 428.1 mi
    8h 25m
    $74–106

  5. Bus to Pittsburgh International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Wheeling Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Chicago O'Hare International Airport (ORD)plane plane PIT - ORD
    6h 25m
    $66–380

  6. Bus to John Glenn Columbus International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Wheeling Bus Stop to Columbusbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Chicago Midway International Airport (MDW)plane plane CMH - MDW
    6h 31m
    $111–595

  7. Bus, bus to Akron, fly to Chicago O'Hare International Airport

    1. Take the bus from Wheeling Bus Stop to Cambridge, OHbus bus
    2. Take the bus from Cambridge to Cantonbus bus
    3. Fly from Akron (CAK) to Chicago O'Hare International Airport (ORD)plane plane CAK - ORD
    7h 45m
    $57–318

  8. Bus (Flixbus)

    1. Take the bus from Wheeling Bus Stop to Chicago Bus Stationbus bus FlixBus N2642
    11h 40m
    $85–140

Wheeling to Chicago by bus

Calendar14Weekly Buses
Duration11h 10mAverage Duration
Ticket$53Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Wheeling to Chicago.ExpandLaunch map view
  • Distance: 492.9 mi
  • Duration: 6h 2m

What companies run services between Wheeling, WV, USA and Chicago, IL, USA?

You can take a bus from Wheeling Bus Stop to Chicago via Columbus in around 11h 10m.

Airlines
Train operators
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Need to know: Greyhound

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