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How to get fromWheeling to Greenvilleby bus, plane, bus (Greyhound), train, or car

Find Transport to Greenville

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There are 6 ways to get from Wheeling to Greenville by bus, plane, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly

    best
    1. Take the bus from Wheeling Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Greenville–Spartanburg International Airport (GSP)plane plane PIT - GSP
    5h 30m
    $141–691

  2. Drive 498.6 mi

    cheapest
    1. Drive from Wheeling to Greenvillecar car 498.6 mi
    9h 19m
    $91–132

  3. Bus

    1. Take the bus from Wheeling Bus Stop to Cambridge, OHbus bus
    2. Take the bus from Cambridge to Charleston, WVbus bus
    3. Take the bus from Charleston, WV to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    14h 54m
    $95–209

  4. Bus, train

    1. Take the bus from Wheeling Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Take the train from Pittsburgh Amtrak Station to Carytrain train
    3. Take the train from Cary to Charlotte Amtrak Stationtrain train
    4. Take the bus from Charlotte to Taqueria Guadalajara - Greenvillebus bus
    24h 58m
    $277–583

  5. Bus to John Glenn Columbus International Airport, fly

    1. Take the bus from Wheeling Bus Stop to Columbusbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Greenville–Spartanburg International Airport (GSP)plane plane CMH - GSP
    6h 18m
    $163–735

  6. Bus via Atlanta

    1. Take the bus from Wheeling Bus Stop to Columbusbus bus
    2. Take the bus from Columbus to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    26h 42m
    $162–298

Pittsburgh International Airport (PIT) to Greenville–Spartanburg International Airport (GSP) flights

Calendar58Weekly Planes
Duration3h 30mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from Wheeling to Greenville.ExpandLaunch map view
  • Distance: 489.4 mi
  • Duration: 5h 30m

What companies run services between Wheeling, WV, USA and Greenville, SC, USA?

You can take a bus from Wheeling Bus Stop to Greenville via Cambridge, OH, Cambridge, Charleston, WV, Charlotte Bus Station, Trade St & Graham St, Transit Center- Bay A, Transit Center- Bay O, Tryon St & Dorton St, Charlotte, and Taqueria Guadalajara - Greenville in around 14h 54m.

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