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How to get fromWheeling to St. Louisby bus, plane, bus (Greyhound), car, or train

Find Transport to St. Louis

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There are 5 ways to get from Wheeling to St. Louis by bus, plane, bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Pittsburgh International Airport, fly

    best
    1. Take the bus from Wheeling Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Fly from Pittsburgh International Airport (PIT) to Lambert–St. Louis International Airport (STL)plane plane PIT - STL
    6h 8m
    $115–649

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Wheeling Bus Stop to St Louis Bus Stationbus bus Greyhound US0421
    11h 40m
    $80–160

  3. Drive 543.1 mi

    1. Drive from Wheeling to St. Louiscar car 543.1 mi
    9h 3m
    $100–144

  4. Bus to John Glenn Columbus International Airport, fly

    1. Take the bus from Wheeling Bus Stop to Columbusbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    6h 48m
    $833–955

  5. Bus, train to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Wheeling Bus Stop to Pittsburgh Intermodal Stationbus bus
    2. Take the train from Pittsburgh Amtrak Station to Cleveland Amtraktrain train
    3. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    9h 24m
    $550–1,017

Wheeling to St. Louis by bus (Greyhound)

Calendar14Weekly Buses
Duration11h 40mAverage Duration
Ticket$80Cheapest Price
See schedules

Questions & Answers

Map of how to get from Wheeling to St. Louis.ExpandLaunch map view
  • Distance: 640.5 mi
  • Duration: 6h 8m

What companies run services between Wheeling, WV, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Wheeling Bus Stop to St Louis Bus Station twice daily. Tickets cost $80–160 and the journey takes 11h 40m.

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