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How to get fromWilkes-Barre to St. Louisby plane, bus (Greyhound), bus, train, or car

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There are 7 ways to get from Wilkes-Barre to St. Louis by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Wilkes-Barre/Scranton International Airport

    best
    1. Fly from Wilkes-Barre/Scranton International Airport (AVP) to Lambert–St. Louis International Airport (STL)plane plane AVP - STL
    5h 32m
    $216–866

  2. Bus

    cheapest
    1. Take the bus from Wilkes Barre, Pa to Harrisburg, Pabus bus 771
    2. Take the bus from Harrisburg Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    21h 30m
    $142–302

  3. Bus, train

    1. Take the bus from Scranton Bus Station to Syracuse Bus Stationbus bus
    2. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    24h 8m
    $330–699

  4. Drive 866.5 mi

    1. Drive from Wilkes-Barre to St. Louiscar car 866.5 mi
    14h 31m
    $159–229

  5. Bus to Philadelphia International Airport, fly

    1. Take the bus from Wilkes-Barre to Philadelphia 30th St Stationbus bus
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    8h 27m
    $212–887

  6. Bus to Laguardia Airport, fly

    1. Take the bus from Wilkes-Barre to Port Authority Bus Terminalbus bus
    2. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    8h 7m
    $213–537

  7. Bus, bus to Newark Liberty International Airport, fly

    1. Take the bus from Wilkes-Barre to Port Authority Bus Terminalbus bus
    2. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    3. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    8h 30m
    $465–919

Wilkes-Barre to St. Louis by bus

Calendar7Weekly Buses
Duration21h 30mAverage Duration
Ticket$142Cheapest Price
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Questions & Answers

Map of how to get from Wilkes-Barre to St. Louis.ExpandLaunch map view
  • Distance: 818.9 mi
  • Duration: 5h 32m

What companies run services between Wilkes-Barre, PA, USA and St. Louis, MO, USA?

American Airlines and United Airlines fly from Wilkes-Barre/Scranton International Airport (AVP) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Wilkes Barre, Pa to St Louis Bus Station via Harrisburg Bus Station in around 21h 30m.

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