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How to get fromWilmington to Chicagoby train, plane, train (Amtrak), bus (Greyhound), car, or bus

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There are 8 ways to get from Wilmington to Chicago by train, plane, train (Amtrak), bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly to Chicago Midway International Airport

    best
    1. Take the train from Wilmington to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane plane PHL - MDW
    4h 42m
    $151–920

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Wilmington Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0305 / ...
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    20h 55m
    $121–240

  3. Train via Washington (Amtrak)

    1. Take the train from Wilmington to Washington Union Stationtrain train Northeast Regional / ...
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train Floridian
    20h 37m
    $267–1,114

  4. Drive 739.2 mi

    1. Drive from Wilmington to Chicagocar car 739.2 mi
    12h 35m
    $135–195

  5. Train to Baltimore-Washington International Airport, fly to Chicago Midway International Airport

    1. Take the train from Wilmington to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Chicago Midway International Airport (MDW)plane plane BWI - MDW
    4h 47m
    $140–891

  6. Train to Philadelphia International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Wilmington to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago O'Hare International Airport (ORD)plane plane PHL - ORD
    5h 11m
    $131–770

  7. Train, bus

    1. Take the train from Wilmington to Jefferson Stationtrain train Wil
    2. Take the bus from Philadelphia Bus Station to Readingbus bus
    3. Take the bus from Reading to Chicago Bus Stationbus bus
    23h 37m
    $142–248

  8. Train (Amtrak)

    1. Take the train from Wilmington to Chicago Union Stationtrain train Cardinal
    26h 40m
    $320–700

Wilmington to Chicago by train and subway (Amtrak)

Calendar7Weekly Services
Duration20h 37mAverage Duration
Ticket$267Cheapest Price
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Questions & Answers

Map of how to get from Wilmington to Chicago.ExpandLaunch map view
  • Distance: 710.5 mi
  • Duration: 4h 42m

What companies run services between Wilmington, DE, USA and Chicago, IL, USA?

You can take a train from Wilmington to Chicago Union Station via Washington Union Station, Union Station, Red Line Center Platform, Rockville, Red Line Center Platform, and Rockville Amtrak in around 20h 37m. Alternatively, you can take a bus from Wilmington Bus Station to Chicago Bus Station via Baltimore Downtown Bus Station in around 20h 55m.

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